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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorCallejo, Angela
dc.contributor.authorMolina, Maria del Mar
dc.contributor.authorDinarès Fernández, Mª Carme
dc.contributor.authorHernandez Losa, Javier
dc.contributor.authorPlanas Ribas, Bibiana
dc.contributor.authorGarcia Perez, Jorge Nestor
dc.contributor.authorCurran Fàbregas, Adria
dc.contributor.authorNavarro Mercadé, Jordi
dc.contributor.authorSuanzes Diez, Paula
dc.contributor.authorFalcó Ferrer, Vicenç
dc.contributor.authorBurgos Cibrian, Joaquin
dc.date.accessioned2022-09-09T14:44:48Z
dc.date.available2022-09-09T14:44:48Z
dc.date.issued2022-08-01
dc.identifier.citationCallejo A, Del Mar Molina M, Dinares MC, Hernández-Losa J, Planas B, Garcia J, et al. Exploratory study of an oral screening dysplasia program for HIV-infected men who have sex with men. AIDS. 2022 Aug 1;36(10):1383–91.
dc.identifier.issn1473-5571
dc.identifier.urihttp://hdl.handle.net/11351/8130
dc.descriptionDysplasia; Screening; HIV-infected
dc.description.abstractBackground: HIV-infected men who have sex with men (MSM) are at high risk to develop human papilloma virus (HPV)-related oropharyngeal cancer. The aim of our study was to assess the usefulness of a pilot oral dysplasia screening program and its correlation with an anal dysplasia screening program. Methods: This was a prospective study with HIV-infected MSM. Oral and anal screenings were performed based on HPV determination, liquid cytology, direct and microscopy oral examinations, high-resolution anoscopy and biopsies, if necessary. Results: A total of 103 patients were included. The mean age of the patients was 44.6 years, 55.3% were smokers, and 57.3% had a history of previous anal high-grade squamous intraepithelial lesions (HSILs). The prevalence of oral HPV infections was 14% (9% HPV-high risk), the prevalence of abnormal cytology was 25.2%, and in 4.8% of the patients, oral examinations showed suspicious HSILs. Oral microscopy did not detect additional lesions that visual inspection. Five oral biopsies were performed and the results were normal. No risk factors for oral HPV infections were identified. The prevalence of anal HPV infections was 88.3% (76.7% HPV-high risk), 52.9% of the patients had altered cytology, and in 45.6% anoscopy showed changes suggestive of HSILs. Seventy-two anal biopsies were performed, detecting 25 cases of HSILs (24.3%). A poor correlation was observed between oral and anal HPV infections (κ = 0.037). Conclusions: The prevalence of oral HPV infections, abnormal cytology and lesions in HIV-infected MSM was low, and their correlation with anal HPV-related lesions was slight. These results confirm the current barriers to oral dysplasia screening techniques.
dc.language.isoeng
dc.publisherWolters Kluwer Health
dc.relation.ispartofseriesAIDS;36(10)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScientia
dc.subjectAnus - Malalties - Epidemiologia
dc.subjectInfeccions per VIH - Epidemiologia
dc.subjectPapil·lomavirus
dc.subject.meshHIV Infections
dc.subject.meshPapillomavirus Infections
dc.subject.meshAnus Neoplasms
dc.titleExploratory study of an oral screening dysplasia program for HIV-infected men who have sex with men
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1097/QAD.0000000000003287
dc.subject.decsinfecciones por VIH
dc.subject.decsinfecciones por Papillomavirus
dc.subject.decsneoplasias del ano
dc.relation.publishversionhttp://dx.doi.org/10.1097/QAD.0000000000003287
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Callejo A] Universitat Autònoma de Barcelona, Bellaterra, Spain. Hospital Universitari Germans Trias i Pujol, Badalona, Spain, Department of Otorhinolaryngology. [Del Mar Molina M, Planas B, Garcia J, Curran A, Navarro J, Suanzes P, Falcó V, Burgos J] Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Dinares MC, Hernández-Losa J] Universitat Autònoma de Barcelona, Bellaterra, Spain. Servei d’Anatomia Patològica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
dc.identifier.pmid35730367
dc.identifier.wos000829504400007
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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