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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorHoeben, Bianca
dc.contributor.authorPazos, Montserrat
dc.contributor.authorSeravalli, Enrica
dc.contributor.authorBosman, Mirjam
dc.contributor.authorLosert, Christoph
dc.contributor.authorAlbert, Michael
dc.contributor.authorMico Milla, Soraya
dc.date.accessioned2022-09-12T08:33:02Z
dc.date.available2022-09-12T08:33:02Z
dc.date.issued2022-08
dc.identifier.citationHoeben BAW, Pazos M, Seravalli E, Bosman ME, Losert C, Albert MH, et al. ESTRO ACROP and SIOPE recommendations for myeloablative total body irradiation in children. Radiother Oncol. 2022 Aug;173:119–33.
dc.identifier.issn0167-8140
dc.identifier.urihttp://hdl.handle.net/11351/8141
dc.descriptionConsensus recommendations; Pediatric; Total Body Irradiation
dc.description.abstractBackground and purpose Myeloablative Total Body Irradiation (TBI) is an important modality in conditioning for allogeneic hematopoietic stem cell transplantation (HSCT), especially in children with high-risk acute lymphoblastic leukemia (ALL). TBI practices are heterogeneous and institution-specific. Since TBI is associated with multiple late adverse effects, recommendations may help to standardize practices and improve the outcome versus toxicity ratio for children. Material and methods The European Society for Paediatric Oncology (SIOPE) Radiotherapy TBI Working Group together with ESTRO experts conducted a literature search and evaluation regarding myeloablative TBI techniques and toxicities in children. Findings were discussed in bimonthly virtual meetings and consensus recommendations were established. Results Myeloablative TBI in HSCT conditioning is mostly performed for high-risk ALL patients or patients with recurring hematologic malignancies. TBI is discouraged in children <3–4 years old because of increased toxicity risk. Publications regarding TBI are mostly retrospective studies with level III–IV evidence. Preferential TBI dose in children is 12–14.4 Gy in 1.6–2 Gy fractions b.i.d. Dose reduction should be considered for the lungs to <8 Gy, for the kidneys to ≤10 Gy, and for the lenses to <12 Gy, for dose rates ≥6 cGy/min. Highly conformal techniques i.e. TomoTherapy and VMAT TBI or Total Marrow (and/or Lymphoid) Irradiation as implemented in several centers, improve dose homogeneity and organ sparing, and should be evaluated in studies. Conclusions These ESTRO ACROP SIOPE recommendations provide expert consensus for conventional and highly conformal myeloablative TBI in children, as well as a supporting literature overview of TBI techniques and toxicities.
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesRadiotherapy and Oncology;173
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectInfants
dc.subjectCèl·lules mare hematopoètiques - Trasplantació - Complicacions
dc.subjectRadioteràpia
dc.subject.meshHematopoietic Stem Cell Transplantation
dc.subject.mesh/adverse effects
dc.subject.meshWhole-Body Irradiation
dc.subject.meshChild, Preschool
dc.titleESTRO ACROP and SIOPE recommendations for myeloablative Total Body Irradiation in children
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.radonc.2022.05.027
dc.subject.decstrasplante de células madre hematopoyéticas
dc.subject.decs/efectos adversos
dc.subject.decsirradiación corporal total
dc.subject.decsniño preescolar
dc.relation.publishversionhttps://doi.org/10.1016/j.radonc.2022.05.027
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Hoeben BAW] Dept. of Radiation Oncology, University Medical Center Utrecht, The Netherlands. Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. [Pazos M, Losert C] Dept. of Radiation Oncology, University Hospital, LMU Munich, Germany. [Seravalli E, Bosman ME] Dept. of Radiation Oncology, University Medical Center Utrecht, The Netherlands. [Albert MH] Dept. of Pediatrics, Dr. von Hauner Children’s Hospital, University Hospital, LMU Munich, Germany. [Mico Milla S] Servei d’Oncologia Radioteràpica, Vall d'Hebron Hospital Universitari, Barcelona, Spain
dc.identifier.pmid35661674
dc.identifier.wos000806106000001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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