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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorSchmutzler, Rita
dc.contributor.authorSchmitz-Luhn, Bjoern
dc.contributor.authorBorisch, Bettina
dc.contributor.authorDevilee, Peter
dc.contributor.authorEccles, Diana M
dc.contributor.authorHall, Per
dc.contributor.authorBalmaña Gelpí, Judith
dc.date.accessioned2022-09-12T08:56:17Z
dc.date.available2022-09-12T08:56:17Z
dc.date.issued2022-04
dc.identifier.citationSchmutzler RK, Schmitz-Luhn B, Borisch B, Devilee P, Eccles D, Hall P, et al. Risk-Adjusted Cancer Screening and Prevention (RiskAP): Complementing Screening for Early Disease Detection by a Learning Screening Based on Risk Factors. Breast Care. 2022 Apr;17(2):208–23.
dc.identifier.issn1869-6961
dc.identifier.urihttp://hdl.handle.net/11351/8144
dc.descriptionBreast cancer; Evidence-generating care; Risk-adjusted prevention
dc.description.abstractBackground: Risk-adjusted cancer screening and prevention is a promising and continuously emerging option for improving cancer prevention. It is driven by increasing knowledge of risk factors and the ability to determine them for individual risk prediction. However, there is a knowledge gap between evidence of increased risk and evidence of the effectiveness and efficiency of clinical preventive interventions based on increased risk. This gap is, in particular, aggravated by the extensive availability of genetic risk factor diagnostics, since the question of appropriate preventive measures immediately arises when an increased risk is identified. However, collecting proof of effective preventive measures, ideally by prospective randomized preventive studies, typically requires very long periods of time, while the knowledge about an increased risk immediately creates a high demand for action. Summary: Therefore, we propose a risk-adjusted prevention concept that is based on the best current evidence making needed and appropriate preventive measures available, and which is constantly evaluated through outcome evaluation, and continuously improved based on these results. We further discuss the structural and procedural requirements as well as legal and socioeconomical aspects relevant for the implementation of this concept.
dc.language.isoeng
dc.publisherKarger Publishers
dc.relation.ispartofseriesBreast Care;17(2)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceScientia
dc.subjectMama - Càncer - Factors de risc
dc.subjectMama - Càncer - Prevenció
dc.subjectMama - Càncer - Diagnòstic
dc.subject.meshBreast Neoplasms
dc.subject.mesh/prevention & control
dc.subject.meshEarly Detection of Cancer
dc.subject.meshRisk Factors
dc.titleRisk-Adjusted Cancer Screening and Prevention (RiskAP): Complementing Screening for Early Disease Detection by a Learning Screening Based on Risk Factors
dc.typeinfo:eu-repo/semantics/article
dc.subject.decsneoplasias de la mama
dc.subject.decs/prevención & control
dc.subject.decsdetección precoz del cáncer
dc.subject.decsfactores de riesgo
dc.relation.publishversionhttps://doi.org/10.1159/000517182
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Schmutzler RK] Center Familial Breast and Ovarian Cancer and Center of Integrated Oncology (CIO), University Hospital Cologne, Cologne, Germany. [Schmitz-Luhn B] Cologne Center for Ethics, Rights, Economics, and Social Sciences of Health (ceres), University of Cologne, and Research Unit Ethics, University Hospital of Cologne, Cologne, Germany. [Borisch B] Institute of Global Health, University of Geneva, Geneva, Switzerland. [Devilee P] Leids Universitair Medisch Zentrum, Universiteit Leiden, Leiden, The Netherlands. [Eccles D] Clinical Trials Unit, University of Southampton, Southampton, UK. [Hall P] Karolinska Institutet, Stockholm, Sweden. [Balmaña J] Vall d'Hebron Institute of Oncology (VHIO), Barcelona, Spain
dc.identifier.pmid35702492
dc.identifier.wos10.1159/000517182
dc.identifier.wos000811438400003
dc.relation.projectidinfo:eu-repo/grantAgreement/EC/H2020/634935
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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