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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorBatista, Lissette
dc.contributor.authorRobles Alonso, Virginia
dc.contributor.authorManichanh, Chaysavanh
dc.contributor.authorRuiz, Laura
dc.contributor.authorGuagnozzi, Danila
dc.contributor.authorPinsach Batet, Ferran
dc.contributor.authorGuarner Aguilar, Francisco
dc.contributor.authorFernández-Bañares, Fernando
dc.date.accessioned2022-09-13T06:39:32Z
dc.date.available2022-09-13T06:39:32Z
dc.date.issued2022-06-28
dc.identifier.citationBatista L, Robles V, Manichanh C, Ruiz L, Guagnozzi D, Pinsach F, et al. Colonic bacterial diversity and dysbiosis in active microscopic colitis as compared to chronic diarrhoea and healthy controls: effect of polyethylene glycol after bowel lavage for colonoscopy. BMC Gastroenterol. 2022 Jun 28;22:320.
dc.identifier.issn1471-230X
dc.identifier.urihttp://hdl.handle.net/11351/8169
dc.descriptionFaecal microbiome; Microscopic colitis; Polyethylene glycol
dc.description.abstractBackground Most microbiota studies in microscopic colitis patients are performed after diagnostic colonoscopy without considering the potential effect of colonic lavage. Patients may achieve clinical remission after colonoscopy and it is unknown whether lavage-induced changes play a role. Aim To assess the effect of polyethylene glycol (PEG) colonic lavage on clinical remission rate, microbial diversity, microbial dysbiosis index and specific microbial changes in patients with active microscopic colitis as compared to other diarrhoeal diseases and healthy controls. Methods Fifty-five consecutive patients presenting chronic watery diarrhoea and 12 healthy controls were included. Faecal samples were collected three days before and 30 days after PEG in patients and controls for microbiome analysis. Results Clinical remission was observed in 53% of microscopic colitis patients, and in 32% of non-microscopic colitis patients (p = 0.16). Considering patients with persisting diarrhoea after colonoscopy, 71% of non-microscopic colitis patients had bile acid diarrhoea. Baseline Shannon Index was lower in diarrhoea groups than in healthy controls (p = 0.0025); there were no differences between microscopic colitis, bile-acid diarrhoea and functional diarrhoea. The microbial dysbiosis index was significantly higher in microscopic colitis than in bile acid diarrhoea plus functional diarrhoea (p = 0.0095), but no bacterial species showed a significantly different relative abundance among the diarrheal groups. Conclusions Dysbiosis is a feature in active microscopic colitis, but loss of microbial diversity was similar in all diarrheal groups, suggesting that faecal microbial changes are not due to microscopic colitis itself but associated with stool form. A considerable number of microscopic colitis patients achieved clinical remission after colonoscopy, but we were unable to demonstrate related PEG-induced changes in faecal microbiome.
dc.language.isoeng
dc.publisherBMC
dc.relation.ispartofseriesBMC Gastroenterology;22
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectDiarrea - Complicacions
dc.subjectColonoscòpia
dc.subjectIntestins - Microbiologia
dc.subject.meshDysbiosis
dc.subject.meshDiarrhea
dc.subject.mesh/complications
dc.subject.meshColonoscopy
dc.titleColonic bacterial diversity and dysbiosis in active microscopic colitis as compared to chronic diarrhoea and healthy controls: effect of polyethylene glycol after bowel lavage for colonoscopy
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1186/s12876-022-02392-w
dc.subject.decsdisbacteriosis
dc.subject.decsdiarrea
dc.subject.decs/complicaciones
dc.subject.decscolonoscopia
dc.relation.publishversionhttps://doi.org/10.1186/s12876-022-02392-w
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Batista L, Fernández-Bañares F] Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Spain. Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain. [Robles V, Manichanh C, Guagnozzi D, Guarner F] Unitat de Recerca d’Aparell Digestiu, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Gastroenterologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de enfermedades hepáticas y digestivas (CIBERehd), Instituto de Salud Carlos III, Madrid, Spain. [Ruiz L] Department of Gastroenterology, Hospital Universitari Mutua Terrassa, Terrassa, Spain. [Pinsach F] Unitat de Recerca d’Aparell Digestiu, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Servei de Gastroenterologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.identifier.pmid35764931
dc.identifier.wos000818999200002
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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