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dc.contributorHospital General de Granollers
dc.contributor.authorSans De San Nicolàs, Lídia
dc.contributor.authorFigueras, Ignasi
dc.contributor.authorBonfill Ortí, Montserrat
dc.contributor.authorJesús Gil, Carmen de
dc.contributor.authorGarcía-Jiménez, Irene
dc.contributor.authorGuilabert, Antonio
dc.date.accessioned2022-09-13T07:23:21Z
dc.date.available2022-09-13T07:23:21Z
dc.date.issued2022-06-30
dc.identifier.citationSans-De San Nicolàs L, Figueras-Nart I, Bonfill-Ortí M, De Jesús-Gil C, García-Jiménez I, Guilabert A, et al. SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis. Allergy. 2022 Jun 30.
dc.identifier.urihttp://hdl.handle.net/11351/8173
dc.descriptionAtopic dermatitis; Cutaneous lymphocyte antigen; Skin infections
dc.description.abstractStaphylococcus aureus, memory skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells and IL-13 constitute relevant play-ers in atopic dermatitis (AD) pathogenesis.1 Since circulating CLA+ T cells reflect cutaneous abnormalities present in human inflammatory skin diseases,2 an ex vivo coculture model made of purified circu-lating CLA+/− effector and central memory T cells and autologous lesional epidermal cells was established. We show a CLA-dependent production of IL-13 upon activation with staphylococcal enterotoxin B (SEB) that allows the differentiation of the Th2 high and Th2 low groups, with distinct clinical correlations between both groups, within a clinically homogeneous population of adult non-treated moderate-to- severe AD patients.
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofseriesAllergy;
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceScientia
dc.subjectDermatitis atòpica
dc.subjectEstafilococs daurats
dc.subjectPell - Infeccions
dc.subject.meshDermatitis, Atopic
dc.subject.meshStaphylococcus aureus
dc.subject.meshT-Lymphocytes
dc.titleSEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1111/all.15424
dc.subject.decsdermatitis atópica
dc.subject.decsStaphylococcus aureus
dc.subject.decslinfocitos T
dc.relation.publishversionhttps://doi.org/10.1111/all.15424
dc.type.versioninfo:eu-repo/semantics/acceptedVersion
dc.audienceProfessionals
dc.contributor.authoraffiliation[Sans-De San Nicolàs L, De Jesús-Gil C, García-Jiménez I] Grup d’Immunologia Translacional, Departament de Biologia Cel·lular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona (UB), Parc Científic de Barcelona (PCB), Barcelona, Spain. [Figueras-Nart I, Bonfill-Ortí M] Departament de Dermatologia, Hospital de Bellvitge, Universitat de Barcelona (UB), L’Hospitalet de Llobregat, Spain. [Guilabert A] Departament de Dermatologia, Hospital General de Granollers, Granollers, Spain
dc.identifier.pmid35773619
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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