dc.contributor | Hospital General de Granollers |
dc.contributor.author | Bonfill Ortí, Montserrat |
dc.contributor.author | Jesús Gil, Carmen de |
dc.contributor.author | García-Jiménez, Irene |
dc.contributor.author | Sans De San Nicolàs, Lídia |
dc.contributor.author | Figueras, Ignasi |
dc.contributor.author | Guilabert, Antonio |
dc.date.accessioned | 2022-09-13T07:23:21Z |
dc.date.available | 2022-09-13T07:23:21Z |
dc.date.issued | 2022-06-30 |
dc.identifier.citation | Sans-De San Nicolàs L, Figueras-Nart I, Bonfill-Ortí M, De Jesús-Gil C, García-Jiménez I, Guilabert A, et al. SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis. Allergy. 2022 Jun 30. |
dc.identifier.uri | https://hdl.handle.net/11351/8173 |
dc.description | Atopic dermatitis; Cutaneous lymphocyte antigen; Skin infections |
dc.description.abstract | Staphylococcus aureus, memory skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells and IL-13 constitute relevant play-ers in atopic dermatitis (AD) pathogenesis.1 Since circulating CLA+ T cells reflect cutaneous abnormalities present in human inflammatory skin diseases,2 an ex vivo coculture model made of purified circu-lating CLA+/− effector and central memory T cells and autologous lesional epidermal cells was established. We show a CLA-dependent production of IL-13 upon activation with staphylococcal enterotoxin B (SEB) that allows the differentiation of the Th2 high and Th2 low groups, with distinct clinical correlations between both groups, within a clinically homogeneous population of adult non-treated moderate-to- severe AD patients. |
dc.language.iso | eng |
dc.publisher | Wiley |
dc.relation.ispartofseries | Allergy; |
dc.rights | Attribution-NonCommercial 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by-nc/4.0/ |
dc.source | Scientia |
dc.subject | Dermatitis atòpica |
dc.subject | Estafilococs daurats |
dc.subject | Pell - Infeccions |
dc.subject.mesh | Dermatitis, Atopic |
dc.subject.mesh | Staphylococcus aureus |
dc.subject.mesh | T-Lymphocytes |
dc.title | SEB-induced IL-13 production in CLA+ memory T cells defines Th2 high and Th2 low responders in atopic dermatitis |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.1111/all.15424 |
dc.subject.decs | dermatitis atópica |
dc.subject.decs | Staphylococcus aureus |
dc.subject.decs | linfocitos T |
dc.relation.publishversion | https://doi.org/10.1111/all.15424 |
dc.type.version | info:eu-repo/semantics/acceptedVersion |
dc.audience | Professionals |
dc.contributor.authoraffiliation | [Sans-De San Nicolàs L, De Jesús-Gil C, García-Jiménez I] Grup d’Immunologia Translacional, Departament de Biologia Cel·lular, Fisiologia i Immunologia, Facultat de Biologia, Universitat de Barcelona (UB), Parc Científic de Barcelona (PCB), Barcelona, Spain. [Figueras-Nart I, Bonfill-Ortí M] Departament de Dermatologia, Hospital de Bellvitge, Universitat de Barcelona (UB), L’Hospitalet de Llobregat, Spain. [Guilabert A] Departament de Dermatologia, Hospital General de Granollers, Granollers, Spain |
dc.identifier.pmid | 35773619 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |