dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
dc.contributor.author | Saegeman, Veroniek |
dc.contributor.author | Cohen, Marta |
dc.contributor.author | Abasolo, Lydia |
dc.contributor.author | Fernández-Gutierrez, Benjamín |
dc.contributor.author | Fernandez-Rodriguez, Amparo |
dc.contributor.author | Rello, Jordi |
dc.date.accessioned | 2022-09-14T08:14:50Z |
dc.date.available | 2022-09-14T08:14:50Z |
dc.date.issued | 2022-06 |
dc.identifier.citation | Saegeman V, Cohen MC, Abasolo L, Rello J, Fernandez-Gutierrez B, Fernandez-Rodriguez A. Positive airway pressure longer than 24 h is associated with histopathological volutrauma in severe COVID-19 pneumonia—an ESGFOR based narrative case-control review. Ann Transl Med. 2022 Jun;10(11):644. |
dc.identifier.issn | 2305-5847 |
dc.identifier.uri | https://hdl.handle.net/11351/8190 |
dc.description | SARS-CoV-2; Post-mortem microbiology; Volutrauma |
dc.description.abstract | Background and Objective: A thorough understanding of the pathogenic mechanisms elicited by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) still requires further research. Until recently, only a restricted number of autopsies have been performed, therefore limiting the accurate knowledge of the lung injury associated with SARS-CoV-2. A multidisciplinary European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group of Forensic and Post-mortem Microbiology-ESGFOR team conducted a non-systematic narrative literature review among coronavirus 2019 disease (COVID-19) pneumonia cases assessing the histopathological (HP) effects of positive airways pressure. HP lung features were recorded and compared between mechanically ventilated (>24 hours) and control (ventilation <24 hours) patients. A logistic regression analysis was performed to identify associations between mechanical ventilation (MV) and HP findings.
Methods: A PubMed and MEDLINE search was conducted in order to identify studies published between March 1st 2020 and June 30th 2021.
Key Content and Findings: Seventy patients (median age: 69 years) from 24 studies were analysed, among whom 38 (54.2%) underwent MV longer than 24 hours. Overall, main HP features were: diffuse alveolar damage (DAD) in 53 (75.7%), fibrosis (interstitial/intra-alveolar) in 43 (61.4%), vascular damage—including thrombosis/emboli- in 41 (58.5%), and endotheliitis in only 8 (11.4%) patients. Association of DAD, fibrosis and vascular damage was detected in 30 (42.8%) patients. Multivariate analysis, adjusted by age and gender, identified MV >24 hours as an independent variable associated with DAD (OR =5.40, 95% CI: 1.48–19.62), fibrosis (OR =3.88, 95% CI: 1.25–12.08), vascular damage (OR =5.49, 95% CI: 1.78–16.95) and association of DAD plus fibrosis plus vascular damage (OR =6.99, 95% CI: 2.04–23.97).
Conclusions: We identified that patients mechanically ventilated >24 hours had a significantly higher rate of pulmonary injury on histopathology independently of age and gender. Our findings emphasize the importance of maintaining a protective ventilator strategy when subjects with COVID-19 pneumonia undergo intubation. |
dc.language.iso | eng |
dc.publisher | AME Publishing Company |
dc.relation.ispartofseries | Annals of Translational Medicine;10(11) |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
dc.source | Scientia |
dc.subject | COVID-19 (Malaltia) - Complicacions |
dc.subject | Respiració artificial - Complicacions |
dc.subject | Pneumònia vírica |
dc.subject.mesh | Coronavirus Infections |
dc.subject.mesh | Respiration, Artificial |
dc.subject.mesh | /adverse effects |
dc.subject.mesh | Pneumonia |
dc.title | Positive airway pressure longer than 24 h is associated with histopathological volutrauma in severe COVID-19 pneumonia—an ESGFOR based narrative case-control review |
dc.type | info:eu-repo/semantics/article |
dc.identifier.doi | 10.21037/atm-22-605 |
dc.subject.decs | infecciones por Coronavirus |
dc.subject.decs | respiración artificial |
dc.subject.decs | /efectos adversos |
dc.subject.decs | neumonía |
dc.relation.publishversion | http://dx.doi.org/10.21037/atm-22-605 |
dc.type.version | info:eu-repo/semantics/publishedVersion |
dc.audience | Professionals |
dc.contributor.organismes | Institut Català de la Salut |
dc.contributor.authoraffiliation | [Saegeman V] Department of Microbiology and Infection Control, Vitaz, Sint-Niklaas, Belgium. Department of Infection Control, University Hospitals, Leuven, Belgium. [Cohen MC] Histopathology Department, Sheffield Children’s NHS FT, Sheffield, UK. [Abasolo L] Rheumatology Department, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IDISSC), Hospital Clínico San Carlos, Madrid, Spain. [Rello J] Grup de Recerca Clínica/Innovació en la Pneumònia i Sèpsia (CRIPS), Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica En Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain. Clinical Research, CHRU Nimes, Nimes, France. [Fernandez-Gutierrez B] Rheumatology Department, Hospital Clinico San Carlos, Madrid, Spain. [Fernandez-Rodriguez A] Microbiology Laboratory, Biology Department, Instituto Nacional de Toxicología y Ciencias Forenses, Las Rozas de Madrid, Madrid, Spain |
dc.identifier.pmid | 35813341 |
dc.identifier.wos | 000809575700001 |
dc.rights.accessrights | info:eu-repo/semantics/openAccess |