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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorFanciulli, Chiara
dc.contributor.authorBerenguer, Juan
dc.contributor.authorBusca, Carmen
dc.contributor.authorVivancos, María J.
dc.contributor.authorTéllez, María J.
dc.contributor.authorDomínguez-Domínguez, Lourdes
dc.contributor.authorNavarro Mercadé, Jordi
dc.date.accessioned2022-09-16T09:34:33Z
dc.date.available2022-09-16T09:34:33Z
dc.date.issued2022-08
dc.identifier.citationFanciulli C, Berenguer J, Busca C, Vivancos MJ, Téllez MJ, Domínguez L, et al. Epidemiological trends of HIV/HCV coinfection in Spain, 2015–2019. HIV Med. 2022 Aug;23(7):705–16.
dc.identifier.issn1468-1293
dc.identifier.urihttp://hdl.handle.net/11351/8205
dc.descriptionEpidemiology; HIV/HCV coinfection; Spain
dc.description.abstractObjectives We assessed the prevalence of anti-hepatitis C virus (HCV) antibodies and active HCV infection (HCV-RNA-positive) in people living with HIV (PLWH) in Spain in 2019 and compared the results with those of four similar studies performed during 2015–2018. Methods The study was performed in 41 centres. Sample size was estimated for an accuracy of 1%. Patients were selected by random sampling with proportional allocation. Results The reference population comprised 41 973 PLWH, and the sample size was 1325. HCV serostatus was known in 1316 PLWH (99.3%), of whom 376 (28.6%) were HCV antibody (Ab)-positive (78.7% were prior injection drug users); 29 were HCV-RNA-positive (2.2%). Of the 29 HCV-RNA-positive PLWH, infection was chronic in 24, it was acute/recent in one, and it was of unknown duration in four. Cirrhosis was present in 71 (5.4%) PLWH overall, three (10.3%) HCV-RNA-positive patients and 68 (23.4%) of those who cleared HCV after anti-HCV therapy (p = 0.04). The prevalence of anti-HCV antibodies decreased steadily from 37.7% in 2015 to 28.6% in 2019 (p < 0.001); the prevalence of active HCV infection decreased from 22.1% in 2015 to 2.2% in 2019 (p < 0.001). Uptake of anti-HCV treatment increased from 53.9% in 2015 to 95.0% in 2019 (p < 0.001). Conclusions In Spain, the prevalence of active HCV infection among PLWH at the end of 2019 was 2.2%, i.e. 90.0% lower than in 2015. Increased exposure to DAAs was probably the main reason for this sharp reduction. Despite the high coverage of treatment with direct-acting antiviral agents, HCV-related cirrhosis remains significant in this population.
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofseriesHIV Medicine;23(7)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceScientia
dc.subjectHepatitis C - Epidemiologia
dc.subjectInfeccions per VIH - Epidemiologia
dc.subject.meshHIV Infections
dc.subject.meshHepatitis C
dc.subject.meshCoinfection
dc.titleEpidemiological trends of HIV/HCV coinfection in Spain, 2015–2019
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1111/hiv.13229
dc.subject.decsinfecciones por VIH
dc.subject.decshepatitis C
dc.subject.decscoinfección
dc.relation.publishversionhttps://doi.org/10.1111/hiv.13229
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Fanciulli C, Berenguer J] Infectious Diseases and Clinical Microbiology, Hospital General Universitario Gregorio Marañón (IiSGM), Madrid, Spain. Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. [Busca C] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. HIV Unit, Internal Medicine, Hospital Universitario La Paz (IdiPAZ), Madrid, Spain. [Vivancos MJ] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. Infectious Diseases, Hospital Ramón y Cajal (Irycis), Madrid, Spain. [Téllez MJ] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. Infectious Diseases, Hospital Clínico San Carlos, Madrid, Spain. [Domínguez L] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. HIV Unit, Internal Medicine, Hospital Universitario 12 de Octubre, Madrid, Spain. [Navarro J] Unit of Infectious Diseases, Hospital Universitario Reina Sofia. Instituto Maimonides de Investigación Biomédica de Córdoba (IMIBIC), Universidad de Córdoba (UCO), Cordoba, Spain. Servei de Malalties Infeccioses, Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.identifier.pmid35037379
dc.identifier.wos000743078100001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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