| dc.contributor | Vall d'Hebron Barcelona Hospital Campus |
| dc.contributor.author | Arts, Rob J. W. |
| dc.contributor.author | Ector, Geneviève |
| dc.contributor.author | Bosch Nicolau, Pau |
| dc.contributor.author | McCall, Matthew B. B. |
| dc.contributor.author | van der Velden, Walter J. F. M. |
| dc.contributor.author | Molina Romero, Israel |
| dc.date.accessioned | 2023-04-27T11:52:52Z |
| dc.date.available | 2023-04-27T11:52:52Z |
| dc.date.issued | 2023 |
| dc.identifier.citation | Arts RJW, Ector GICG, Bosch-Nicolau P, Molina I, McCall MBB, van der Velden WJFM, et al. A difficult to treat Leishmania infantum relapse after allogeneic stem cell transplantation. IDCases. 2023;32:e01753. |
| dc.identifier.issn | 2214-2509 |
| dc.identifier.uri | https://hdl.handle.net/11351/9435 |
| dc.description | Amphotericin B; Leishmania; Pancytopenia |
| dc.description.abstract | Here we describe a complicated case of a relapsed Leishmania infantum infection after an allogeneic stem cell transplantation (allo-SCT) for primary myelofibrosis. Three years earlier the patient had been diagnosed with a hemophagocytic lymphohistiocytosis secondary to a visceral Leishmania infantum infection, for which he was effectively treated with a cumulative dose of 40 mg/kg liposomal amphotericin B. During the first disease episode he was also diagnosed with primary myelofibrosis for which he received medical follow-up. One year later ruxolitinib was started due to progressive disease. No Leishmania relapse occurred. Nevertheless, the marrow fibrosis progressed, and an allo-SCT was performed. Two months after allo-SCT prolonged fever and a persistent pancytopenia occurred, which was due to a relapse of visceral Leishmaniasis. The infection was refractory to a prolonged treatment with liposomal amphotericin B with a cumulative dose up to 100 mg/kg. Salvage treatment with miltefosine led to reduction of fever within a few days and was followed by a slow recovery of pancytopenia over the following months. The Leishmania parasite load by PCR started to decline and after 3.5 months no Leishmania DNA could be detected anymore and follow-up until ten months afterwards did not show a relapse. |
| dc.language.iso | eng |
| dc.publisher | Elsevier |
| dc.relation.ispartofseries | IDCases;32 |
| dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ |
| dc.source | Scientia |
| dc.subject | Leishmaniosi - Recaiguda |
| dc.subject | Malalties parasitàries - Recaiguda |
| dc.subject.mesh | Leishmania infantum |
| dc.subject.mesh | Parasitic Diseases |
| dc.subject.mesh | Recurrence |
| dc.title | A difficult to treat Leishmania infantum relapse after allogeneic stem cell transplantation |
| dc.type | info:eu-repo/semantics/article |
| dc.identifier.doi | 10.1016/j.idcr.2023.e01753 |
| dc.subject.decs | Leishmania infantum |
| dc.subject.decs | enfermedades parasitarias |
| dc.subject.decs | recurrencia |
| dc.relation.publishversion | https://doi.org/10.1016/j.idcr.2023.e01753 |
| dc.type.version | info:eu-repo/semantics/publishedVersion |
| dc.audience | Professionals |
| dc.contributor.organismes | Institut Català de la Salut |
| dc.contributor.authoraffiliation | [Arts RJW] Department of Internal Medicine, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboudumc Center for Infectious Diseases (RCI), Radboud University Medical Center, Nijmegen, the Netherlands. [Ector GICG, van der Velden WJFM] Department of Hematology, Radboud University Medical Center, Radboud Institute of Molecular Life Sciences (RIMLS), Nijmegen, the Netherlands. [Bosch-Nicolau P, Molina I] Servei de Malalties Infeccioses, Centre de Salut Internacional i Malalties Transmissibles Drassanes-Vall d'Hebron Hospital Universitari, Barcelona, Spain. PROSICS Barcelona, CSUR Imported Tropical Diseases, Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Institute of Health Carlos III, Madrid, Spain. [McCall MBB] Department of Medical Microbiology, Radboud Institute of Molecular Life Sciences (RIMLS) and Radboudumc Center for Infectious Diseases (RCI), Radboud University Medical Center, GA Nijmegen, the Netherlands |
| dc.identifier.pmid | 37063784 |
| dc.rights.accessrights | info:eu-repo/semantics/openAccess |