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Homologous recombination repair status in metastatic prostate cancer by next-generation sequencing and functional immunofluorescence

dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorArce Gallego, Sara
dc.contributor.authorRomero-Lozano, Paula
dc.contributor.authorMir Arnau, Gisela
dc.contributor.authorAguilar, Daniel
dc.contributor.authorMast, Richard
dc.contributor.authorCresta Morgado, Pablo
dc.contributor.authorDelgado-Serrano, Luisa
dc.contributor.authorSimonetti, Sara
dc.contributor.authorMacarena, Gonzalez
dc.contributor.authorMarmolejo Castañeda, David Humberto
dc.contributor.authorMorales-Barrera, Rafael
dc.contributor.authorSemidey Raven, Maria Eugenia
dc.contributor.authorCordoba, Sarai
dc.contributor.authorde Albert de Delás-Vigo, Matias
dc.contributor.authorPlanas, Jacques
dc.contributor.authorCuadras Solé, Mercè
dc.contributor.authorMaldonado, Xavier
dc.contributor.authorCasanova-Salas, Irene
dc.contributor.authorMas Malavila, Alba
dc.contributor.authorNonell, Lara
dc.contributor.authorDienstmann, Rodrigo
dc.contributor.authorNuciforo, Paolo
dc.contributor.authorVivancos, Ana
dc.contributor.authorLlop-Guevara, Alba
dc.contributor.authorSerra, Violeta
dc.contributor.authorMateo, Joaquin
dc.contributor.authorCarles, Joan
dc.contributor.authorSuárez, Cristina
dc.date.accessioned2025-03-31T09:57:47Z
dc.date.available2025-03-31T09:57:47Z
dc.date.issued2025-02-18
dc.identifier.citationArce-Gallego S, Cresta Morgado P, Delgado-Serrano L, Simonetti S, Gonzalez M, Romero-Lozano P, et al. Homologous recombination repair status in metastatic prostate cancer by next-generation sequencing and functional immunofluorescence. Cell Reports Med. 2025 Feb 18;6(2):101937.
dc.identifier.issn2666-3791
dc.identifier.urihttp://hdl.handle.net/11351/12845
dc.descriptionGenòmica; Immunofluorescència; Càncer de pròstata
dc.description.sponsorshipThis work was funded by an Impact Award from the Department of Defense CDMRP (PC170510P1) and a grant from AstraZeneca (ESR-21-21360). The funders had no role in the design or conduction of the study and were not involved in the analysis or interpretation of results. CRIS Cancer Foundation (grant TCL_2020-10) and Fundación AECC (LABAE20019MATE) and a Department of Defense Physician Science Award to J.M. (PC220307). S.A.-G. was supported by Instituto de Salud Carlos III (FI19/00280). P.C.M. was supported by an ESMO Translational Research Fellowship, funded by BMS (any views, opinions, findings, conclusions, or recommendations expressed in this material are those solely of the authors and do not necessarily reflect those of ESMO or BMS). I.C.-S. was supported by a Prostate Cancer Foundation YIA (24YOU12). A.L.-G. was supported by an AECC grant (INVES20095LLOP), and V.S. received funding from an ERA PerMed grant (ERAPERMED2019-215). The VHIO authors would like to acknowledge the Spanish State Agency for Research (Agencia Estatal de Investigación) for its financial support as a Center of Excellence Severo Ochoa (CEX2020-001024-S/AEI/10.13039/501100011033), the Cellex Foundation for providing research facilities and equipment, and the CERCA Program from the Generalitat de Catalunya for their support of this research.
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesCell Reports Medicine;6(2)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScientia
dc.subjectAnomalies cromosòmiques
dc.subjectPròstata - Càncer - Aspectes genètics
dc.subjectSeqüència de nucleòtids
dc.subjectMetàstasi
dc.subjectADN - Reparació
dc.subject.meshMutation
dc.subject.meshNeoplasm Metastasis
dc.subject.meshProstatic Neoplasms
dc.subject.mesh/genetics
dc.subject.meshRecombinational DNA Repair
dc.subject.meshHigh-Throughput Nucleotide Sequencing
dc.titleHomologous recombination repair status in metastatic prostate cancer by next-generation sequencing and functional immunofluorescence
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.xcrm.2025.101937
dc.subject.decsmutación
dc.subject.decsmetástasis neoplásica
dc.subject.decsneoplasias de la próstata
dc.subject.decs/genética
dc.subject.decsreparación del ADN por recombinación
dc.subject.decssecuenciación de nucleótidos de alto rendimiento
dc.relation.publishversionhttps://doi.org/10.1016/j.xcrm.2025.101937
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Arce-Gallego S, Delgado-Serrano L, Mir Arnau G, Aguilar D, Cordoba-Terreros S, Casanova-Salas I] Prostate Cancer Research, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Cresta Morgado P] Prostate Cancer Research, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Oncology Data Science (OdysSey) Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Simonetti S, Nuciforo P] Molecular Oncology, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Gonzalez M, Marmolejo D, Morales-Barrera R, Suarez C, Carles J, Mateo J] Prostate Cancer Research, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Servei d’Oncologia Mèdica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Romero-Lozano P, Vivancos A] Cancer Genomics Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Semidey ME] Servei d’Anatomia Patològica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Mast R, de Albert M] Servei de Radiodiagnòstic, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Planas J, Cuadras M] Servei d’Urologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Maldonado X] Servei d’Oncologia Radioteràpica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Mas A, Nonell L] Bioinformatics Unit, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. [Dienstmann R] Oncology Data Science (OdysSey) Group, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. University of Vic - Central University of Catalonia, Vic, Spain. [Llop-Guevara A, Serra V] Experimental Therapeutics, Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain
dc.identifier.pmid39914385
dc.identifier.wos001433264900001
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2017-2020/FI19%2F00280
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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