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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorAlbert Bayo, Mercè
dc.contributor.authorParacuellos Ayala, Irene
dc.contributor.authorGonzalez Castro, Ana Maria
dc.contributor.authorRodríguez Urrutia, Amanda
dc.contributor.authorRodríguez-Lagunas, Maria J
dc.contributor.authorAlonso Cotoner, Carmen
dc.contributor.authorSantos Vicente, Fco Javier
dc.contributor.authorVicario Perez, Maria
dc.date.accessioned2019-03-08T13:15:55Z
dc.date.available2019-03-08T13:15:55Z
dc.date.issued2019-02-08
dc.identifier.citationAlbert-Bayo M, Paracuellos I, González-Castro AM, Rodríguez-Urrutia A, Rodríguez-Lagunas MJ, Alonso-Cotoner C, et al. Intestinal Mucosal Mast Cells: Key Modulators of Barrier Function and Homeostasis. Cells. 2019;8(2):135.
dc.identifier.issn2073-4409
dc.identifier.urihttp://hdl.handle.net/11351/3838
dc.descriptionIntestinal barrier function; Mucosal mast cells
dc.description.abstractThe gastrointestinal tract harbours the largest population of mast cells in the body; this highly specialised leukocyte cell type is able to adapt its phenotype and function to the microenvironment in which it resides. Mast cells react to external and internal stimuli thanks to the variety of receptors they express, and carry out effector and regulatory tasks by means of the mediators of different natures they produce. Mast cells are fundamental elements of the intestinal barrier as they regulate epithelial function and integrity, modulate both innate and adaptive mucosal immunity, and maintain neuro-immune interactions, which are key to functioning of the gut. Disruption of the intestinal barrier is associated with increased passage of luminal antigens into the mucosa, which further facilitates mucosal mast cell activation, inflammatory responses, and altered mast cell⁻enteric nerve interaction. Despite intensive research showing gut dysfunction to be associated with increased intestinal permeability and mucosal mast cell activation, the specific mechanisms linking mast cell activity with altered intestinal barrier in human disease remain unclear. This review describes the role played by mast cells in control of the intestinal mucosal barrier and their contribution to digestive diseases.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesCells;8(2)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScientia
dc.subjectMastòcits
dc.subjectMucosa intestinal - Citologia
dc.subjectHomeòstasi
dc.subject.meshMast Cells
dc.subject.meshIntestinal Mucosa
dc.subject.mesh/cytology
dc.subject.meshHomeostasis
dc.titleIntestinal Mucosal Mast Cells: Key Modulators of Barrier Function and Homeostasis
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/cells8020135
dc.subject.decsmastocitos
dc.subject.decsmucosa intestinal
dc.subject.decs/citología
dc.subject.decshomeostasis
dc.relation.publishversionhttps://www.mdpi.com/2073-4409/8/2/135
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Albert-Bayo M, Paracuellos I, González-Castro AM] Unitat de Recerca de Malalties Digestives, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. [Rodríguez-Urrutia A] Servei de Psiquiatria, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona, Barcelona, Spain. Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Madrid, Spain. [Rodríguez-Lagunas MJ] Department of Biochemistry and Physiology, Faculty of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain. [Alonso-Cotoner C, Santos J] Unitat de Recerca de Malalties Digestives, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Servei de Gastroenterologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain. Centro de Investigación Biomédica en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain. [Vicario M] Unitat de Recerca de Malalties Digestives, Vall d’Hebron Institut de Recerca, Barcelona, Spain. Hospital Universitari Vall d'Hebron, Barcelona, Spain. Centro de Investigación Biomédica en Enfermedades Hepáticas y Digestivas (CIBEREHD), Madrid, Spain.
dc.identifier.pmid30744042
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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