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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorVu, Diem-Lan
dc.contributor.authorSabrià, Aurora
dc.contributor.authorAregall, Nuria
dc.contributor.authorMichl, Kristina
dc.contributor.authorRodríguez Garrido, Virginia
dc.contributor.authorGoterris Bonet, Lidia
dc.date.accessioned2019-08-07T06:27:18Z
dc.date.available2019-08-07T06:27:18Z
dc.date.issued2019-06-27
dc.identifier.citationVu D-L, Sabrià A, Aregall N, Michl K, Rodriguez Garrido V, Goterris L, et al. Novel Human Astroviruses: Prevalence and Association with Common Enteric Viruses in Undiagnosed Gastroenteritis Cases in Spain. Viruses. 2019;11(7):e585.
dc.identifier.issn1999-4915
dc.identifier.urihttp://hdl.handle.net/11351/4249
dc.descriptionAdenovirus; Children; Classic astrovirus
dc.description.abstractA remarkable percentage of acute gastroenteritis cases remain etiologically undiagnosed. The aim of the study was to determine the prevalence of common and emerging enteric viruses, such as novel human astroviruses, among undiagnosed samples from children with acute gastroenteritis. Epidemiological studies for novel human astroviruses are still scarce. Stool samples collected over two consecutive winter seasons (2016-2017) from children with gastroenteritis in Spain, which were negative for bacteria, rotavirus, and adenovirus by routine diagnostics were screened by real-time RT-PCR assays for the presence of classical and novel astrovirus, rotavirus, norovirus GI and GII, sapovirus, and adenovirus. Overall, 220/384 stool samples (57.3%) were positive for at least one virus. Co-infections were identified in 21% of cases. Among a total of 315 viruses identified, adenovirus was the most prevalent (n = 103), followed by rotavirus (n = 51), sapovirus (n = 50), classical astrovirus (n = 43), novel astroviruses (n = 42), and norovirus (n = 26). Novel astroviruses were present in 13.3% of virus-positive cases. Most novel astroviruses were found in children <2-year-old (30/39 children, 77%, p = 0.01) and were found in co-infection (66%). Only classical astroviruses demonstrated significant differences in the Cq values during mono-infections compared to co-infections. In conclusion, common enteric viruses may be frequently found in children with undiagnosed gastroenteritis, indicating the need to implement more sensitive diagnostic methods. Novel astroviruses circulate in the community and could be the cause of gastroenteritis among young children.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesViruses;11(7)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectVirus RNA
dc.subjectGastroenteritis en els infants - Epidemiologia - Espanya
dc.subject.meshGastroenteritis
dc.subject.meshAstroviridae Infections
dc.subject.mesh/epidemiology
dc.subject.meshChild, Preschool
dc.subject.meshSpain
dc.titleNovel Human Astroviruses: Prevalence and Association with Common Enteric Viruses in Undiagnosed Gastroenteritis Cases in Spain
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/v11070585
dc.subject.decsgastroenteritis
dc.subject.decsinfecciones por Astroviridae
dc.subject.decs/epidemiología
dc.subject.decsniño preescolar
dc.subject.decsEspaña
dc.relation.publishversionhttps://www.mdpi.com/1999-4915/11/7/585
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Vu DL] Laboratori de Virus Entèric, Departament de Genètica, Microbiologia i Estadística, Universitat de Barcelona, Barcelona, Spain. Institut de Recerca en Nutrició i Seguretat Alimentària, Universitat de Barcelona, Santa Coloma de Gramenet, Spain. Department of Infectious Diseases, Geneva University Hospitals, Geneva, Switzerland. [Sabrià A] Laboratori de Virus Entèric, Departament de Genètica, Microbiologia i Estadística, Universitat de Barcelona, Barcelona, Spain. Institut de Recerca en Nutrició i Seguretat Alimentària, Universitat de Barcelona, Santa Coloma de Gramenet, Spain. [Aregall N, Michl K] Laboratori de Virus Entèric, Departament de Genètica, Microbiologia i Estadística, Universitat de Barcelona, Barcelona, Spain. [Rodriguez Garrido V, Goterris L] Servei de Microbiologia, Hospital Universitari Vall d'Hebron, Barcelona, Spain.
dc.identifier.pmid31252663
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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