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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorBeaulieu, Marie-Eve
dc.contributor.authorSoucek, Laura
dc.date.accessioned2021-03-19T09:43:19Z
dc.date.available2021-03-19T09:43:19Z
dc.date.issued2019-06-20
dc.identifier.citationBeaulieu ME, Soucek L. Finding MYCure. Mol Cell Oncol. 2019 Jun 20;6(5):e1618178.
dc.identifier.issn2372-3556
dc.identifier.urihttp://hdl.handle.net/11351/5775
dc.descriptionMYC; Peptide therapeutic; Mini-protein
dc.description.abstractInhibiting the nuclear protein MYC involved in the majority of human cancers has long been considered an impossible mission and several technical challenges have discouraged the development of MYC inhibitory strategies. Nevertheless, in our recent publication in Science Translational Medicine "Intrinsic cell-penetrating activity propels Omomyc from proof of concept to viable anti-MYC therapy", we demonstrate for the first time the feasibility of pharmacological MYC inhibition in vitro and in vivo using an Omomyc-based mini-protein.
dc.language.isoeng
dc.publisherTaylor and Francis
dc.relation.ispartofseriesMolecular & Cellular Oncology;6(5)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScientia
dc.subjectPèptids
dc.subjectOncogens
dc.subject.meshPeptide Fragments
dc.subject.mesh/administration & dosage
dc.subject.meshProto-Oncogene Proteins c-myc
dc.titleFinding MYCure
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1080/23723556.2019.1618178
dc.subject.decsfragmentos peptídicos
dc.subject.decs/administración & dosificación
dc.subject.decsproteínas protooncogénicas c-myc
dc.relation.publishversionhttps://www.tandfonline.com/doi/full/10.1080/23723556.2019.1618178
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Beaulieu ME] Peptomyc S.L., Edifici Cellex, Barcelona, Spain. [Soucek L] Peptomyc S.L., Edifici Cellex, Barcelona, Spain. Vall d’Hebron Institute of Oncology (VHIO), Barcelona, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. Departament de Bioquímica i de Biologia Molecular, Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.identifier.pmid31528695
dc.identifier.wos000485086600009
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/PI13%2F01705
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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