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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorSegura Ginard, Miguel
dc.contributor.authorJubierre Zapater, Luz
dc.contributor.authorLi, SiDe
dc.contributor.authorSoriano Fernández, Aroa
dc.contributor.authorKoetz, Lisa
dc.contributor.authorGaziel-Sovran, Avital
dc.contributor.authorMasanas Jimenez, Marc
dc.date.accessioned2021-04-27T09:53:12Z
dc.date.available2021-04-27T09:53:12Z
dc.date.issued2017-04-18
dc.identifier.citationSegura MF, Jubierre L, Li S, Soriano A, Koetz L, Gaziel-Sovran A, et al. Krüppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions. Oncotarget. 2017 Apr 18;8(16):26298–311.
dc.identifier.issn1949-2553
dc.identifier.urihttp://hdl.handle.net/11351/5909
dc.descriptionEmbryonic stem cells; Melanoma; MicroRNA
dc.description.abstractMicroRNAs (miRNAs) are a class of endogenous non-coding small RNAs that post-transcriptionally control the translation and stability of target mRNAs in a sequence-dependent manner. MiRNAs are essential for key cellular processes including proliferation, differentiation, cell death and metabolism, among others. Consequently, alterations of miRNA expression contribute to developmental defects and a myriad of diseases. The expression of miRNAs can be altered by several mechanisms including gene copy number alterations, aberrant DNA methylation, defects of the miRNA processing machinery or unscheduled expression of transcription factors. In this work, we sought to analyze the regulation of the miR-182 cluster, located at the 7q32 locus, which encodes three different miRNAs that are abundantly expressed in human embryonic stem cells and de-regulated in cancer. We have found that the Krüppel-like factor 4 (KLF4) directly regulates miR-182 cluster expression in human embryonic stem cells (hESCs) and in melanoma tumors, in which the miR-182 cluster is highly expressed and has a pro-metastatic role. Furthermore, higher KLF4 expression was found to be associated with metastatic progression and poor patient outcome. Loss of function experiments revealed that KLF4 is required for melanoma cell maintenance. These findings provide new insights into the regulation of the miR-182 cluster expression and new opportunities for therapeutic intervention in tumors in which the KLF4-miR-182 cluster axis is deregulated.
dc.language.isoeng
dc.publisherImpact Journals
dc.relation.ispartofseriesOncotarget;8(16)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectTumors
dc.subjectCèl·lules mare embrionàries
dc.subjectFactors de transcripció
dc.subject.meshHuman Embryonic Stem Cells
dc.subject.meshNeoplasms
dc.subject.meshKruppel-Like Transcription Factors
dc.titleKrüppel-like factor 4 (KLF4) regulates the miR-183~96~182 cluster under physiologic and pathologic conditions
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.18632/oncotarget.15459
dc.subject.decscélulas madre embrionarias humanas
dc.subject.decsneoplasias
dc.subject.decsfactores de transcripción similares a Kruppel
dc.relation.publishversionhttps://www.oncotarget.com/article/15459/text/
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Segura MF] Department of Pathology, New York University School of Medicine, New York, NY, USA. Interdisciplinary Melanoma Cooperative Group, New York University Perlmutter Cancer Institute, NYU School of Medicine, New York, NY, USA. Grup Recerca translacional amb càncer infantil, Vall d'Hebron Institut de Rercerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Jubierre L, Soriano A, Masanas M] Grup Recerca translacional amb càncer infantil, Vall d'Hebron Institut de Rercerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Li S] Departments of Structural and Chemical Biology, Genetics and Genomic Sciences and Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [Koetz L, Gaziel-Sovran A] Department of Pathology, New York University School of Medicine, New York, NY, USA. Interdisciplinary Melanoma Cooperative Group, New York University Perlmutter Cancer Institute, NYU School of Medicine, New York, NY, USA
dc.identifier.pmid28412746
dc.identifier.wos000399819700042
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/1PN/2008-2011/CP11%2F00052
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/2PN/2008-2011/RD12%2F0036%2F0016
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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