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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorBarbui, Tiziano
dc.contributor.authorDe Stefano, Valerio
dc.contributor.authorAlvarez-Larran, Alberto
dc.contributor.authorIurlo, Alessandra
dc.contributor.authorMasciulli, Arianna
dc.contributor.authorCarobbio, Alessandra
dc.contributor.authorFox, Maria Laura
dc.date.accessioned2021-06-09T11:01:29Z
dc.date.available2021-06-09T11:01:29Z
dc.date.issued2021-02-04
dc.identifier.citationBarbui T, De Stefano V, Alvarez-Larran A, Iurlo A, Masciulli A, Carobbio A, et al. Among classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19. Blood Cancer J. 2021 Feb 4;11:21.
dc.identifier.issn2044-5385
dc.identifier.urihttp://hdl.handle.net/11351/6042
dc.descriptionCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; nfectious diseases; Myeloproliferative disease; Risk factors
dc.description.abstractIn a multicenter European retrospective study including 162 patients with COVID-19 occurring in essential thrombocythemia (ET, n = 48), polycythemia vera (PV, n = 42), myelofibrosis (MF, n = 56), and prefibrotic myelofibrosis (pre-PMF, n = 16), 15 major thromboses (3 arterial and 12 venous) were registered in 14 patients, of whom all, but one, were receiving LMW-heparin prophylaxis. After adjustment for the competing risk of death, the cumulative incidence of arterial and venous thromboembolic events (VTE) reached 8.5% after 60 days follow-up. Of note, 8 of 12 VTE were seen in ET. Interestingly, at COVID-19 diagnosis, MPN patients had significantly lower platelet count (p < 0.0001) than in the pre-COVID last follow-up.This decline was remarkably higher in ET (−23.3%, p < 0.0001) than in PV (−16.4%, p = 0.1730) and was associated with higher mortality rate (p = 0.0010) for pneumonia. The effects of possible predictors of thrombosis, selected from those clinically relevant and statistically significant in univariate analysis, were examined in a multivariate model. Independent risk factors were transfer to ICU (SHR = 3.73, p = 0.029), neutrophil/lymphocyte ratio (SHR = 1.1, p = 0.001) and ET phenotype (SHR = 4.37, p = 0.006). The enhanced susceptibility to ET-associated VTE and the associated higher mortality for pneumonia may recognize a common biological plausibility and deserve to be delved to tailor new antithrombotic regimens including antiplatelet drugs.
dc.language.isoeng
dc.publisherSpringer Nature
dc.relation.ispartofseriesBlood Cancer Journal;11
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectCOVID-19 (Malaltia) - Factors de risc
dc.subjectTromboembolisme
dc.subject.meshVenous Thromboembolism
dc.subject.meshCoronavirus Infections
dc.subject.mesh/complications
dc.titleAmong classic myeloproliferative neoplasms, essential thrombocythemia is associated with the greatest risk of venous thromboembolism during COVID-19
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/s41408-021-00417-3
dc.subject.decstromboembolia venosa
dc.subject.decsinfecciones por Coronavirus
dc.subject.decs/complicaciones
dc.relation.publishversionhttps://doi.org/10.1038/s41408-021-00417-3
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Barbui T, Masciulli A, Carobbio A] FROM Research Foundation, Papa Giovanni XXIII Hospital, Bergamo, Italy. [De Stefano V] Section of Hematology, Department of Radiological and Hematological Sciences, Catholic University, Fondazione Policlinico “A. Gemelli” IRCCS, Rome, Italy. [Alvarez-Larran A] Hospital Clinic de Barcelona, Barcelona, Spain. [Iurlo A] Hematology Division, Foundation IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy. [Fox ML] Servei d’Hematologia, Vall d’Hebron Institute of Oncology (VHIO), Barcelona Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.identifier.pmid33563901
dc.identifier.wos000618326700001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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