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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorPando Rau, Elizabeth
dc.contributor.authorAlberti Delgado, Piero Arturo
dc.contributor.authorMata Mata, Rodrigo José
dc.contributor.authorGomez Jurado, Maria Jose
dc.contributor.authorVidal Fornells, Laura
dc.contributor.authorCirera De Tudela, Arturo
dc.contributor.authorDopazo Taboada, Cristina
dc.contributor.authorBlanco Cuso, Laia
dc.contributor.authorGomez Gavara, Concepción
dc.contributor.authorCaralt Barba, Mireia
dc.contributor.authorBalsells Valls, Joaquin
dc.contributor.authorCharco Torra, Ramon
dc.date.accessioned2021-06-15T12:39:00Z
dc.date.available2021-06-15T12:39:00Z
dc.date.issued2021-03-22
dc.identifier.citationPando E, Alberti P, Mata R, Gomez MJ, Vidal L, Cirera A, et al. Early Changes in Blood Urea Nitrogen (BUN) Can Predict Mortality in Acute Pancreatitis: Comparative Study between BISAP Score, APACHE-II, and Other Laboratory Markers—A Prospective Observational Study. Can J Gastroenterol Hepatol. 2021 Mar 22;2021:6643595.
dc.identifier.issn2291-2797
dc.identifier.urihttp://hdl.handle.net/11351/6076
dc.descriptionAcute Pancreatitis; Mortality prediction
dc.description.abstractBackground. Changes in BUN have been proposed as a risk factor for complications in acute pancreatitis (AP). Our study aimed to compare changes in BUN versus the Bedside Index for Severity in Acute Pancreatitis (BISAP) score and the Acute Physiology and Chronic Health Evaluation-II score (APACHE-II), as well as other laboratory tests such as haematocrit and its variations over 24 h and C-reactive protein, in order to determine the most accurate test for predicting mortality and severity outcomes in AP. Methods. Clinical data of 410 AP patients, prospectively enrolled for study at our institution, were analyzed. We define AP according to Atlanta classification (AC) 2012. The laboratory test’s predictive accuracy was measured using area-under-the-curve receiver-operating characteristics (AUC) analysis and sensitivity and specificity tests. Results. Rise in BUN was the only score related to mortality on the multivariate analysis (p = 0.000, OR: 12.7; CI 95%: 4.2−16.6). On the comparative analysis of AUC, the rise in BUN was an accurate test in predicting mortality (AUC: 0.842) and persisting multiorgan failure (AUC: 0.828), similar to the BISAP score (AUC: 0.836 and 0.850) and APACHE-II (AUC: 0.756 and 0.741). The BISAP score outperformed both APACHE-II and rise in BUN at 24 hours in predicting severe AP (AUC: 0.873 vs. 0.761 and 0.756, respectively). Conclusion. Rise in BUN at 24 hours is a quick and reliable test in predicting mortality and persisting multiorgan failure in AP patients.
dc.language.isoeng
dc.publisherHindawi
dc.relation.ispartofseriesCanadian Journal of Gastroenterology and Hepatology;2021
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectPancreatitis - Mortalitat
dc.subjectSang - Examen
dc.subjectPrognosi
dc.subject.meshBlood Urea Nitrogen
dc.subject.meshPancreatitis
dc.subject.mesh/mortality
dc.subject.meshPredictive Value of Tests
dc.titleEarly Changes in Blood Urea Nitrogen (BUN) Can Predict Mortality in Acute Pancreatitis: Comparative Study between BISAP Score, APACHE-II, and Other Laboratory Markers—A Prospective Observational Study
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1155/2021/6643595
dc.subject.decsnitrógeno ureico sanguíneo
dc.subject.decspancreatitis
dc.subject.decs/mortalidad
dc.subject.decsvalor predictivo de las pruebas
dc.relation.publishversionhttps://www.hindawi.com/journals/cjgh/2021/6643595/
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliationServei de Cirurgia Hepatobiliopancreàtica i Trasplantaments, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain
dc.identifier.pmid33824864
dc.identifier.wos000637346100001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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