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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorRiveiro Barciela, Maria del Mar
dc.contributor.authorGubern, Paula
dc.contributor.authorRoade Tato, Maria Luisa
dc.contributor.authorAbrisqueta Costa, Pablo
dc.contributor.authorCarreras Soler, Maria Josep
dc.contributor.authorFarriols Danes, Anna Maria
dc.contributor.authorBosch Albareda, Francesc
dc.contributor.authorEsteban Mur, Rafael
dc.contributor.authorButi Ferret, Maria
dc.date.accessioned2021-09-03T10:48:24Z
dc.date.available2021-09-03T10:48:24Z
dc.date.issued2020-02-20
dc.identifier.citationRiveiro-Barciela M, Gubern P, Roade L, Abrisqueta P, Carreras MJ, Farriols A, et al. An electronic alert system increases screening for hepatitis B and C and improves management of patients with haematological disorders. Sci Rep. 2020 Feb 20;10:3038.
dc.identifier.issn2045-2322
dc.identifier.urihttp://hdl.handle.net/11351/6267
dc.descriptionHepatitis B; Hepatitis C
dc.description.abstractTreatment of haematological disorders in patients with chronic hepatitis B or resolved infection (anti-HBc-positive) is associated with a risk of hepatitis B reactivation. Moreover, patients with chronic hepatitis C have a higher risk of haematological malignancies than general population. An electronic alert system was developed to promote screening of hepatitis B (HBV) and C (HCV) in patients starting haematological therapies. The system included screening and linkage to care and a request for testing in those without data. From March, 2017 to March, 2018 data from 420 consecutive patients with haematological diseases were included. At first prescription before the alerts, the HCV and HBV screening rate was 60.5%. Following the alerts, an additional 115 were screened, increasing the overall screening rate to 87.9%. Anti-HBc alone was detected in 57, anti-HCV in 13, and HBsAg in 2 patients. Overall, 68% of patients with any viral hepatitis markers were previously not know, and the impact was particularly important for anti-HBc detection (47/57 unknown). Nucleoside analogues were prescribed in 28 (49.1%) anti-HBc-positive and the 2 HBsAg-positive patients. Prospective follow-up with HBV DNA and HBsAg testing showed no cases of HBV reactivation. An estimated 1.2 HBV reactivations were avoided as consequence of the alert system. In summary, an electronic alert system increased viral hepatitis screening in patients receiving haematological treatment and led to improvements in the management of these patients, including avoided HBV reactivation.
dc.language.isoeng
dc.publisherNature Research
dc.relation.ispartofseriesScientific Reports;10
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectSang - Malalties
dc.subjectElectrònica mèdica
dc.subjectDiagnòstic
dc.subject.meshHematologic Diseases
dc.subject.meshElectronics, Medical
dc.subject.meshDiagnosis
dc.titleAn electronic alert system increases screening for hepatitis B and C and improves management of patients with haematological disorders
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/s41598-020-59476-4
dc.subject.decsenfermedades hematológicas
dc.subject.decselectrónica médica
dc.subject.decsdiagnóstico
dc.relation.publishversionhttps://doi.org/10.1038/s41598-020-59476-4
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Riveiro-Barciela M, Esteban R, Buti M] Unitat del Fetge, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBERehd), Barcelona, Spain. [Gubern P, Roade L] Unitat del Fetge, Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Abrisqueta P, Bosch F] Servei d’Hematologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Carreras MJ, Farriols A] Servei de Farmàcia, Vall d’Hebron Hospital Universitari, Barcelona, Spain
dc.identifier.pmid32080253
dc.identifier.wos000563079900022
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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