Show simple item record

 
dc.contributorIDIAP Jordi Gol
dc.contributor.authorLlor, Carla
dc.contributor.authorOuchi, Dan
dc.contributor.authorGiner-Soriano, Maria
dc.contributor.authorGarcia-Sangenis, Ana
dc.contributor.authorBjerrum, Lars
dc.contributor.authorMorros, Rosa
dc.date.accessioned2021-11-12T08:42:23Z
dc.date.available2021-11-12T08:42:23Z
dc.date.issued2021-11-08
dc.identifier.citationLlor C, Ouchi D, Giner-Soriano M, García-Sangenís A, Bjerrum L, Morros R. Correlation between previous antibiotic exposure and COVID-19 severity: a population-based cohort study. Antibiotics. 2021 Nov 8;10(11):1364.
dc.identifier.issn2079-6382
dc.identifier.urihttp://hdl.handle.net/11351/6534
dc.descriptionDrug resistance; Primary health care; COVID-19; Anti-bacterial agents
dc.description.abstractWe examined the correlation between previous antibiotic exposure and COVID-19 severity using a population-based observational matched cohort study with patient level data obtained for more than 5.8 million people registered in SIDIAP in Catalonia, Spain. We included all patients newly diagnosed with COVID-19 from March to June 2020 and identified all their antibiotic prescriptions in the previous two years. We used a composite severity endpoint, including pneumonia, hospital admission and death due to COVID-19. We examined the influence of high antibiotic exposure (>4 regimens), exposure to highest priority critically important antimicrobials (HPCIA) and recent exposure. Potential confounders were adjusted by logistic regression. A total of 280,679 patients were diagnosed with COVID-19, 146,656 of whom were exposed to at least one antibiotic course (52.3%) during the preceding two years. A total of 25,222 presented severe COVID-19 infection (9%), and the risk of severity was highest among those exposed to antibiotics (OR 1.12; 95% CI: 1.04–1.21). Among all individuals exposed to antibiotics, high, recent and exposure to HPCIAs were correlated with increased COVID severity (OR 1.19; 95% CI: 1.14–1.26; 1.41; 95% CI: 1.36–1.46; and 1.35; 95% CI: 1.30–1.40, respectively). Our findings confirm a significant correlation between previous antibiotic exposure and increased severity of COVID-19 disease.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesAntibiotics;10(11)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScientia
dc.subjectCOVID-19 (Malaltia)
dc.subjectAntibiòtics
dc.subject.meshCoronavirus Infections
dc.subject.meshAnti-Bacterial Agents
dc.subject.meshCorrelation of Data
dc.titleCorrelation between previous antibiotic exposure and COVID-19 severity: a population-based cohort study
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/antibiotics10111364
dc.subject.decsinfecciones por Coronavirus
dc.subject.decsantibacterianos
dc.subject.decscorrelación de datos
dc.relation.publishversionhttps://www.mdpi.com/2079-6382/10/11/1364
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.authoraffiliation[Llor C] Fundació Institut Universitari per la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. Department of Public Health, General Practice, University of Southern Denmark, Odense, Denmark. [Ouchi D, Giner-Soriano M] Fundació Institut Universitari per la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [García-Sangenís A] Fundació Institut Universitari per la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. [Bjerrum L] Section and Research Unit of General Practice, Department of Public Health, University of Copenhagen, Copenhagen, Denmark. [Morros R] Fundació Institut Universitari per la Recerca a l’Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), Barcelona, Spain. Departament de Farmacologia, Terapèutica i Toxicologia, Universitat Autònoma de Barcelona, Bellaterra, Spain. Plataforma SCReN, IICEC IDIAP Jordi Gol, Barcelona, Spain
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record