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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorRuperti-Repilado, Francisco Javier
dc.contributor.authorTobler, Daniel
dc.contributor.authorGreutmann, Matthias
dc.contributor.authorBouchardy, Judith
dc.contributor.authorLadouceur, Magalie
dc.contributor.authorDos Subirá, Laura
dc.date.accessioned2021-12-21T13:39:38Z
dc.date.available2021-12-21T13:39:38Z
dc.date.issued2021-04-21
dc.identifier.citationRuperti-Repilado FJ, Tobler D, Greutmann M, Bouchardy J, Ladouceur M, Dos-Subira L, et al. Risk stratification of adults with congenital heart disease during the COVID-19 pandemic: insights from a multinational survey among European experts. Open Heart. 2021 Apr 21;8:e001455.
dc.identifier.issn2053-3624
dc.identifier.urihttp://hdl.handle.net/11351/6720
dc.descriptionCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Congenital; Heart defects
dc.description.abstractObjective Adults with congenital heart disease (ACHD) may be at a higher risk of a fatal outcome in case of COVID-19. Current risk stratification among these patients relies on personal experience and extrapolation from patients with acquired heart disease. We aimed to provide an expert view on risk stratification while awaiting results from observational studies. Methods This study was an initiative of the EPOCH (European Collaboration for Prospective Outcome Research in Congenital Heart disease). Among nine European countries (Austria, Belgium, Denmark, France, Germany, Italy, the Netherlands, Spain and Switzerland), 24 experts from 23 tertiary ACHD centres participated in the survey. ACHD experts were asked to identify ACHD-specific COVID-19 risk factors from a list of potential outcome predictors and to estimate the risk of adverse COVID-19 outcomes in seven commonly seen patient scenarios. Results 82% of participants did not consider all ACHD patients at risk of COVID-19 related complications. There was a consensus on pulmonary arterial hypertension, Fontan physiology and cyanotic heart disease as risk factors for adverse outcomes. Among different ACHD scenarios, a patient with Eisenmenger syndrome was considered to be at the highest risk. There was a marked variability in risk estimation among the other potential outcome predictors and ACHD scenarios. Conclusions Pulmonary arterial hypertension, Fontan palliation and cyanotic heart disease were widely considered as risk factors for poor outcome in COVID-19. However, there was a marked disparity in risk estimation for other clinical scenarios. We are in urgent need of outcome studies in ACHD suffering from COVID-19.
dc.language.isoeng
dc.publisherBMJ
dc.relation.ispartofseriesOpen heart;8
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceScientia
dc.subjectPandèmia de COVID-19, 2020-
dc.subjectCardiopatia congènita
dc.subjectRiscos per a la salut - Avaluació
dc.subject.meshHeart Defects, Congenital
dc.subject.meshCoronavirus Infections
dc.subject.meshRisk Assessment
dc.titleRisk stratification of adults with congenital heart disease during the COVID-19 pandemic: insights from a multinational survey among European experts
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1136/openhrt-2020-001455
dc.subject.decscardiopatías congénitas
dc.subject.decsinfecciones por Coronavirus
dc.subject.decsevaluación de riesgos
dc.relation.publishversionhttp://dx.doi.org/10.1136/openhrt-2020-001455
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Ruperti-Repilado FJ] Center for Congenital Heart Disease, Cardiology, Inselspital University Hospital Bern, University of Bern, Bern, Switzerland. [Tobler D] Division of Cardiology, University Hospital Basel, University of Basel, Basel, Switzerland. [Greutmann M] University Heart Centre Zurich, Department of Cardiology, University of Zurich, Zurich, Switzerland. [Bouchardy J] Cardiovascular Department, Lausanne University Hospital and University of Lausanne, Lausanne, Switzerland. Service de Cardiologie, University Hospital of Geneva, Geneve, Switzerland. [Ladouceur M] Adult Congenital Heart Disease Unit, Centre de Référence des Malformations Cardiaques Congénitales Complexes, M3C, Inserm U970, Paris Centre de Recherche Cardiovasculaire, Hôpital Europeen Georges-Pompidou Pôle Cardio-vasculaire Rénal Métabolique, Paris, France. [Dos-Subira L] Unitat Integrada de Cardiopaties Congènites de l'Adolescent i l'Adult, Vall d'Hebron Hospital Universitari, Barcelona, Spain - Sant Pau. CIBERCV, Barcelona, Spain
dc.identifier.pmid33883228
dc.identifier.wos000644328900002
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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