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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorCapdevila, Lluis
dc.contributor.authorCastro Marrero, Jesus
dc.contributor.authorAlegre Martin, José
dc.contributor.authorRamos-Castro, Juan
dc.contributor.authorEscorihuela, Rosa M
dc.date.accessioned2022-01-20T09:24:23Z
dc.date.available2022-01-20T09:24:23Z
dc.date.issued2021-05-28
dc.identifier.citationCapdevila L, Castro-Marrero J, Alegre J, Ramos-Castro J, Escorihuela RM. Analysis of Gender Differences in HRV of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Mobile-Health Technology. Sensors. 2021 May 28;21(11):3746.
dc.identifier.issn1424-8220
dc.identifier.urihttp://hdl.handle.net/11351/6841
dc.descriptionChronic fatigue syndrome; Gender differences; Heart rate variability
dc.description.abstractIn a previous study using mobile-health technology (mHealth), we reported a robust association between chronic fatigue symptoms and heart rate variability (HRV) in female patients with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). This study explores HRV analysis as an objective, non-invasive and easy-to-apply marker of ME/CFS using mHealth technology, and evaluates differential gender effects on HRV and ME/CFS core symptoms. In our methodology, participants included 77 ME/CFS patients (32 men and 45 women) and 44 age-matched healthy controls (19 men and 25 women), all self-reporting subjective scores for fatigue, sleep quality, anxiety, and depression, and neurovegetative symptoms of autonomic dysfunction. The inter-beat cardiac intervals are continuously monitored/recorded over three 5-min periods, and HRV is analyzed using a custom-made application (iOS) on a mobile device connected via Bluetooth to a wearable cardiac chest band. Male ME/CFS patients show increased scores compared with control men in all symptoms and scores of fatigue, and autonomic dysfunction, as with women in the first study. No differences in any HRV parameter appear between male ME/CFS patients and controls, in contrast to our findings in women. However, we have found negative correlations of ME/CFS symptomatology with cardiac variability (SDNN, RMSSD, pNN50, LF) in men. We have also found a significant relationship between fatigue symptomatology and HRV parameters in ME/CFS patients, but not in healthy control men. Gender effects appear in HF, LF/HF, and HFnu HRV parameters. A MANOVA analysis shows differential gender effects depending on the experimental condition in autonomic dysfunction symptoms and HF and HFnu HRV parameters. A decreased HRV pattern in ME/CFS women compared to ME/CFS men may reflect a sex-related cardiac autonomic dysfunction in ME/CFS illness that could be used as a predictive marker of disease progression. In conclusion, we show that HRV analysis using mHealth technology is an objective, non-invasive tool that can be useful for clinical prediction of fatigue severity, especially in women with ME/CFS.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesSensors;21(11)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectSíndrome de fatiga crònica - Diagnòstic
dc.subjectMalalties - Factors sexuals
dc.subjectTecnologia mèdica
dc.subject.meshFatigue Syndrome, Chronic
dc.subject.mesh/diagnosis
dc.subject.meshSex Characteristics
dc.subject.meshBiomedical Technology
dc.titleAnalysis of Gender Differences in HRV of Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Using Mobile-Health Technology
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/s21113746
dc.subject.decssíndrome de fatiga crónica
dc.subject.decs/diagnóstico
dc.subject.decscaracterísticas sexuales
dc.subject.decstecnología biomédica
dc.relation.publishversionhttps://doi.org/10.3390/s21113746
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Capdevila L] Departament de Psicologia Bàsica, Sport Research Institute, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain. [Castro-Marrero J, Alegre J] Unitat d’Encefalomielitis Miàlgica/Síndrome de Fatiga Crònica, Divisió de Reumatologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Ramos-Castro J] Biomedical and Electronic Instrumentation Group, Department of Electronic Engineering, Universitat Politècnica de Catalunya, 08034 Barcelona, Spain. [Escorihuela RM] Departament de Psiquiatria i Medicina Legal, Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain
dc.identifier.pmid34071326
dc.identifier.wos000660681500001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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