Show simple item record

 
dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorWinkler, Martin S.
dc.contributor.authorSkirecki, Tomasz
dc.contributor.authorBrunkhorst, Frank M.
dc.contributor.authorCajander, Sara
dc.contributor.authorCavaillon, Jean-Marc
dc.contributor.authorFerrer Roca, Ricard
dc.date.accessioned2022-03-21T09:14:03Z
dc.date.available2022-03-21T09:14:03Z
dc.date.issued2021-04
dc.identifier.citationWinkler MS, Skirecki T, Brunkhorst FM, Cajander S, Cavaillon JM, Ferrer R, et al. Bridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge. EBioMedicine. 2021 Apr;66:103291.
dc.identifier.issn2352-3964
dc.identifier.urihttp://hdl.handle.net/11351/7220
dc.descriptionAnimal model; COVID-19; Pre-clinical research
dc.description.abstractMany milestones in medical history rest on animal modeling of human diseases. The SARS-CoV-2 pandemic has evoked a tremendous investigative effort primarily centered on clinical studies. However, several animal SARS-CoV-2/COVID-19 models have been developed and pre-clinical findings aimed at supporting clinical evidence rapidly emerge. In this review, we characterize the existing animal models exposing their relevance and limitations as well as outline their utility in COVID-19 drug and vaccine development. Concurrently, we summarize the status of clinical trial research and discuss the novel tactics utilized in the largest multi-center trials aiming to accelerate generation of reliable results that may subsequently shape COVID-19 clinical treatment practices. We also highlight areas of improvement for animal studies in order to elevate their translational utility. In pandemics, to optimize the use of strained resources in a short time-frame, optimizing and strengthening the synergy between the preclinical and clinical domains is pivotal.
dc.language.isoeng
dc.publisherElsevier
dc.relation.ispartofseriesEBioMedicine;66
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectCOVID-19 (Malaltia) - Tractament
dc.subjectVacunes
dc.subjectModels animals en la investigació
dc.subject.meshCoronavirus Infections
dc.subject.mesh/therapy
dc.subject.meshDisease Models, Animal
dc.subject.meshVaccines
dc.titleBridging animal and clinical research during SARS-CoV-2 pandemic: A new-old challenge
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1016/j.ebiom.2021.103291
dc.subject.decsinfecciones por Coronavirus
dc.subject.decs/terapia
dc.subject.decsmodelos de enfermedad en animales
dc.subject.decsvacunas
dc.relation.publishversionhttps://doi.org/10.1016/j.ebiom.2021.103291
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Winkler MS] Department of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, Göttingen, Göttingen, Germany. [Skirecki T] Laboratory of Flow Cytometry, Centre of Postgraduate Medical Education, Warsaw, Poland. [Brunkhorst FM] Dept. of Anesthesiology and Intensive Care Medicine & Center for Sepsis Control and Care (CSCC), Jena University Hospital-Friedrich Schiller University, Jena, Germany. Center for Clinical Studies, Jena University Hospital, Jena, Germany. [Cajander S] Department of Infectious Diseases, Faculty of Medicine and Health, Örebro University, Sweden. [Cavaillon JM] French National Research Agency (ANR), Paris, France. [Ferrer R] Servei de Cures Intensives i Xoc, Grup de Recerca en Disfunció Orgànica i Reanimació, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Centro de Investigación Biomedica En Red-Enfermedades Respiratorias, Instituto de salud Carlos III (ISCIII), Madrid, Spain
dc.identifier.pmid33813139
dc.identifier.wos000647447600005
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record