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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorPuig-Domingo, Manel
dc.contributor.authorBernabéu, Ignacio
dc.contributor.authorPicó, Antonio
dc.contributor.authorBiagetti Biagetti, Betina
dc.contributor.authorGil, Joan
dc.contributor.authorAlvarez-Escolá, Cristina
dc.date.accessioned2022-03-21T09:21:18Z
dc.date.available2022-03-21T09:21:18Z
dc.date.issued2021-03-16
dc.identifier.citationPuig-Domingo M, Bernabéu I, Picó A, Biagetti B, Gil J, Alvarez-Escolá C, et al. Pasireotide in the Personalized Treatment of Acromegaly. Front Endocrinol. 2021 Mar 16;12:648411.
dc.identifier.issn1664-2392
dc.identifier.urihttp://hdl.handle.net/11351/7222
dc.descriptionEndocrine tumors; Growth hormone; Somatotroph adenoma
dc.description.abstractThe delay in controlling the disease in patients who do not respond to first-line treatment with first generation somatostatin receptor ligands (first-generation SRLs) can be quantified in years, as every modification in the medical therapy requires some months to be fully evaluated. Considering this, acromegaly treatment should benefit from personalized medicine therapeutic approach by using biomarkers identifying drug response. Pasireotide has been positioned mostly as a compound to be used in first-generation SRLs resistant patients and after surgical failure, but sufficient data are now available to indicate it is a first line therapy for patients with certain characteristics. Pasireotide has been proved to be useful in patients in which hyperintensity T2 MRI signal is shown and in those depicting low SST2 and high expression of SST5, low or mutated AIP condition and sparsely granulated immunohistochemical pattern. This combination of clinical and pathological characteristics is unique for certain patients and seems to cluster in the same cases, strongly suggesting an etiopathogenic link. Thus, in this paper we propose to include this clinico-pathologic phenotype in the therapeutic algorithm, which would allow us to use as first line medical treatment those compounds with the highest potential for achieving the fastest control of GH hypersecretion as well as a positive effect upon tumor shrinkage, therefore accelerating the implementation of precision medicine for acromegaly. Moreover, we suggest the development, validation and clinical use of a pasireotide acute test, able to identify patients responsive to pasireotide LAR as the acute octreotide test is able to do for SRLs.
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.ispartofseriesFrontiers in Endocrinology;12
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectAcromegàlia - Tractament
dc.subjectSomatostatina - Efectes fisiològics
dc.subject.meshAcromegaly
dc.subject.mesh/drug therapy
dc.subject.meshSomatostatin
dc.subject.mesh/pharmacology
dc.titlePasireotide in the Personalized Treatment of Acromegaly
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3389/fendo.2021.648411
dc.subject.decsacromegalia
dc.subject.decs/farmacoterapia
dc.subject.decssomatostatina
dc.subject.decs/farmacología
dc.relation.publishversionhttps://doi.org/10.3389/fendo.2021.648411
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Puig-Domingo M, Gil J] Endocrinology & Nutrition Service, Germans Trias Hospital and Research Institute, Badalona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Bernabéu I] Endocrinology & Nutrition Service, Complejo Universitario de Santiago de Compostela, Santiago de Compostela, Spain. [Picó A] Endocrinology & Nutrition Service, University Hospital, Alicante, Spain. [Biagetti B] Servei d'Endocrinologia i Nutrició, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Alvarez-Escolá C] Endocrinology & Nutrition Service, La Paz Hospital, Madrid, Spain
dc.identifier.pmid33796079
dc.identifier.wos000634822000001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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