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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorTomasa-Irriguible, Teresa M
dc.contributor.authorSabater-Riera, Joan
dc.contributor.authorPérez Carrasco, Marcos
dc.contributor.authorOrtiz Ballujera, Patricia
dc.contributor.authorDíaz-Buendía, Yolanda
dc.contributor.authorNavas-Pérez, Ana
dc.date.accessioned2022-03-24T14:01:22Z
dc.date.available2022-03-24T14:01:22Z
dc.date.issued2021-04
dc.identifier.citationTomasa-Irriguible TM, Sabater-Riera J, Pérez-Carrasco M, Ortiz-Ballujera P, Díaz-Buendía Y, Navas-Pérez A, et al. Augmented renal clearance. An unnoticed relevant event. Sci Prog. 2021 Apr;104(2):1–15.
dc.identifier.issn2047-7163
dc.identifier.urihttp://hdl.handle.net/11351/7261
dc.descriptionCritically ill patient; Glomerular filtrate rate
dc.description.abstractAugmented renal clearance (ARC) is a phenomenon that can lead to a therapeutic failure of those drugs of renal clearance. The purpose of the study was to ascertain the prevalence of ARC in the critically ill patient, to study the glomerular filtration rate (GFR) throughout the follow-up and analyze the concordance between the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) estimation formula and measured GFR. Observational, prospective, multicenter study. ARC was defined as a creatinine clearance greater than 130 ml/min/1.73 m2. Eighteen hospitals were recruited. GFR measurements carried out twice weekly during a 2-month follow-up period. A total of 561 patients were included. ARC was found to have a non-negligible prevalence of 30%. More even, up to 10.7% already had ARC at intensive care unit (ICU) admission. No specific pattern of GFR was found during the follow-up. Patients in the ARC group were younger 56.5 (53.5–58.5) versus 66 (63.5–68.5) years than in the non-ARC group, p < 0.001. ICU mortality was lower in the ARC group, 6.9% versus 14.5%, p = 0.003. There was no concordance between the estimation of GFR by the CKD-EPI formula and GFR calculated from the 4-h urine. ARC is found in up to 30% of ICU patients, so renal removal drugs could be under dosed by up to 30%. And ARC is already detected on admission in 10%. It is a dynamic phenomenon without an established pattern that usually occurs in younger patients that can last for several weeks. And the CKD-EPI formula does not work to estimate the real creatinine clearance of these patients.
dc.language.isoeng
dc.publisherSAGE Publications
dc.relation.ispartofseriesScience Progress;104(2)
dc.rightsAttribution-NonCommercial 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc/4.0/
dc.sourceScientia
dc.subjectRonyons - Malalties - Fisiologia patològica
dc.subjectGlomèruls renals
dc.subjectMedicina intensiva
dc.subject.meshGlomerular Filtration Rate
dc.subject.meshKidney Diseases
dc.subject.mesh/physiopathology
dc.subject.meshIntensive Care Units
dc.titleAugmented renal clearance. An unnoticed relevant event
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1177/00368504211018580
dc.subject.decstasa de filtración glomerular
dc.subject.decsenfermedades renales
dc.subject.decs/fisiopatología
dc.subject.decsunidades de cuidados intensivos
dc.relation.publishversionhttps://doi.org/10.1177/00368504211018580
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Tomasa-Irriguible TM] Intensive Care Department, Germans Trias i Pujol Hospital, Barcelona, Spain. [Sabater-Riera J] Intensive Care Department, Bellvitge Hospital, Barcelona, Spain. [Pérez-Carrasco M] Servei de Cures Intensives, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Ortiz-Ballujera P] Intensive Care Department, Josep Trueta Hospital, Girona, Spain. [Díaz-Buendía Y] Intensive Care Department, Parc de Salut Mar Hospital, Barcelona, Spain. [Navas-Pérez A] Intensive Care Department, Corporació Sanitària Parc Taulí, Sabadell, Spain
dc.identifier.pmid34078190
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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