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dc.contributorHospital General de Granollers
dc.contributor.authorMarti, Sergi
dc.contributor.authorCarsin, Anne-Elie
dc.contributor.authorSampol, Júlia
dc.contributor.authorPallero, Mercedes
dc.contributor.authorAldás Criado, Irene
dc.contributor.authorMarin, Toni
dc.contributor.authorTárrega, Julia
dc.date.accessioned2022-05-20T09:59:28Z
dc.date.available2022-05-20T09:59:28Z
dc.date.issued2022-04-20
dc.identifier.citationMarti S, Carsin AE, Sampol J, Pallero M, Aldas I, Marin T, et al. Higher mortality and intubation rate in COVID-19 patients treated with noninvasive ventilation compared with high-flow oxygen or CPAP. Sci Rep. 2022 Apr 20;12:6527.
dc.identifier.urihttp://hdl.handle.net/11351/7558
dc.descriptionCOVID-19; Noninvasive ventilation; High-flow oxygen
dc.description.abstractThe effectiveness of noninvasive respiratory support in severe COVID-19 patients is still controversial. We aimed to compare the outcome of patients with COVID-19 pneumonia and hypoxemic respiratory failure treated with high-flow oxygen administered via nasal cannula (HFNC), continuous positive airway pressure (CPAP) or noninvasive ventilation (NIV), initiated outside the intensive care unit (ICU) in 10 university hospitals in Catalonia, Spain. We recruited 367 consecutive patients aged ≥ 18 years who were treated with HFNC (155, 42.2%), CPAP (133, 36.2%) or NIV (79, 21.5%). The main outcome was intubation or death at 28 days after respiratory support initiation. After adjusting for relevant covariates and taking patients treated with HFNC as reference, treatment with NIV showed a higher risk of intubation or death (hazard ratio 2.01; 95% confidence interval 1.32-3.08), while treatment with CPAP did not show differences (0.97; 0.63-1.50). In the context of the pandemic and outside the intensive care unit setting, noninvasive ventilation for the treatment of moderate to severe hypoxemic acute respiratory failure secondary to COVID-19 resulted in higher mortality or intubation rate at 28 days than high-flow oxygen or CPAP. This finding may help physicians to choose the best noninvasive respiratory support treatment in these patients.Clinicaltrials.gov identifier: NCT04668196.
dc.language.isoeng
dc.publisherNature Publishing Group
dc.relation.ispartofseriesScientific Reports;12
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectCOVID-19 (Malaltia)
dc.subjectInsuficiència respiratòria
dc.subjectTerapèutica
dc.subject.meshSevere Acute Respiratory Syndrome
dc.subject.meshNoninvasive Ventilation
dc.subject.meshIntubation, Intratracheal
dc.subject.meshCoronavirus Infections
dc.titleHigher mortality and intubation rate in COVID-19 patients treated with noninvasive ventilation compared with high-flow oxygen or CPAP
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1038/s41598-022-10475-7
dc.subject.decssíndrome respiratorio agudo grave
dc.subject.decsventilación no invasiva
dc.subject.decsintubación endotraqueal
dc.subject.decsinfecciones por Coronavirus
dc.relation.publishversionhttps://doi.org/10.1038/s41598-022-10475-7
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.authoraffiliation[Marti S, Sampol J, Pallero M] Respiratory Department, Hospital, Universitari Vall d’Hebron, Barcelona, Spain. Universitat Autònoma de Barcelona (UAB), Barcelona, Spain. CIBER de Enfermedades Respiratorias (CIBERES), Madrid, Spain. [Carsin AE] ISGlobal, Barcelona, Spain. Universitat Pompeu Fabra (UPF), Barcelona, Spain. CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Aldas I, Marin T] Respiratory Department, Hospital Universitari Germans Trias i Pujol, Badalona, Spain. [Tárrega J] Respiratory Department, Hospital General de Granollers, Granollers, Spain. Universitat Internacional de Catalunya, Barcelona, Spain
dc.identifier.pmid35444251
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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