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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorRodriguez-Pinilla, Socorro Maria
dc.contributor.authorSanchez, Joaquin
dc.contributor.authorPerez Seoane, Carlos
dc.contributor.authorLópez-Jiménez, Javier
dc.contributor.authorCarpio Segura, Cecilia Carmen
dc.contributor.authorCastellví Vives, Josep
dc.contributor.authorDomingo Domenech, Eva
dc.contributor.authorCliment, Fina
dc.date.accessioned2022-06-14T07:50:34Z
dc.date.available2022-06-14T07:50:34Z
dc.date.issued2021-01
dc.identifier.citationRodriguez-Pinilla SM, Domingo-Domenech E, Climent F, Sanchez J, Perez Seoane C, Lopez Jimenez J, et al. Clinical and pathological characteristics of peripheral T-cell lymphomas in a Spanish population: a retrospective study. Br J Haematol. 2021 Jan;192(1):82–99.
dc.identifier.issn1365-2141
dc.identifier.urihttps://hdl.handle.net/11351/7679
dc.descriptionAnaplastic large-cell lymphoma; Progression-free survival
dc.description.abstractWe investigated the clinicopathological features and prognostic factors of patients with peripheral T-cell lymphoma (PTCL) in 13 sites across Spain. Relevant clinical antecedents, CD30 expression and staining pattern, prognostic indices using the International Prognostic Index and the Intergruppo Italiano Linfomi system, treatments, and clinical outcomes were examined. A sizeable proportion of 175 patients had a history of immune-related disorders (autoimmune 16%, viral infections 17%, chemo/radiotherapy-treated carcinomas 19%). The median progression-free survival (PFS) and overall survival (OS) were 7·9 and 15·8 months, respectively. Prognostic indices influenced PFS and OS, with a higher number of adverse factors resulting in shorter survival (P < 0·001). Complete response (CR) to treatment was associated with better PFS (62·6 vs. 4 months; P < 0·001) and longer OS (67·0 vs. 7·3 months; P < 0·001) compared to no CR. CD30 was expressed across all subtypes; >15% of cells were positive in anaplastic lymphoma kinase-positive and -negative anaplastic large-cell lymphoma and extranodal natural killer PTCL groups. We observed PTCL distribution across subtypes based on haematopathological re-evaluation. Poor prognosis, effect of specific prognostic indices, relevance of histopathological sub-classification, and response level to first-line treatment on outcomes were confirmed. Immune disorders amongst patients require further examination involving genetic studies and identification of associated immunosuppressive factors.
dc.language.isoeng
dc.publisherWiley
dc.relation.ispartofseriesBritish Journal of Haematology;192(1)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScientia
dc.subjectHodgkin, Malaltia de - Prognosi
dc.subjectAnàlisi de supervivència (Biometria)
dc.subject.meshLymphoma, T-Cell, Peripheral
dc.subject.mesh/diagnosis
dc.subject.meshSurvival Analysis
dc.subject.meshPrognosis
dc.titleClinical and pathological characteristics of peripheral T-cell lymphomas in a Spanish population: a retrospective study
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1111/bjh.16741
dc.subject.decslinfoma de células T periféricas
dc.subject.decs/diagnóstico
dc.subject.decsanálisis de supervivencia
dc.subject.decspronóstico
dc.relation.publishversionhttps://doi.org/10.1111/bjh.16741
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Rodriguez-Pinilla SM] Pathology Department, Hospital Universitario Fundación Jiménez Díaz, Madrid, CIBERONC, Madrid, Spain. [Domingo-Domenech E] Hematology Department, Institut Català d'Oncologia L'Hospitalet de Llobregat (Barcelona), Barcelona, Spain. [Climent F] Pathology Department, Hospital Universitari de Bellvitge. IDIBELL, L'Hospitalet de Llobregat (Barcelona), Barcelona, Spain. [Sanchez J, Perez Seoane C] Hematology Department and Pathology Department, Hospital Universitario Reina Sofía, Cordoba, Spain. [Lopez Jimenez J] Hematology Department, Hospital Universitario Ramón y Cajal, Madrid, Spain. [Carpio C, Castellvi J] Servei d’Hematologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. Servei de Patologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain
dc.identifier.pmid32426847
dc.identifier.wos000533655000001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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