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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorHodcroft, Emma
dc.contributor.authorDyrdak, Robert
dc.contributor.authorAndrés Verges, Cristina
dc.contributor.authorEgli, Adrian
dc.contributor.authorReist, Josiane
dc.contributor.authorGarcía Martínez de Artola, Diego
dc.contributor.authorAntón Pagarolas, Andres
dc.date.accessioned2022-09-08T08:44:34Z
dc.date.available2022-09-08T08:44:34Z
dc.date.issued2022-05-31
dc.identifier.citationHodcroft EB, Dyrdak R, Andrés C, Egli A, Reist J, García Martínez de Artola D, et al. Evolution, geographic spreading, and demographic distribution of Enterovirus D68. PLoS Pathog. 2022 May 31;18(5):e1010515.
dc.identifier.issn1553-7374
dc.identifier.urihttp://hdl.handle.net/11351/8067
dc.descriptionViral evolution; Age distribution; Molecular evolution
dc.description.abstractWorldwide outbreaks of enterovirus D68 (EV-D68) in 2014 and 2016 have caused serious respiratory and neurological disease. We collected samples from several European countries during the 2018 outbreak and determined 53 near full-length genome (‘whole genome’) sequences. These sequences were combined with 718 whole genome and 1,987 VP1-gene publicly available sequences. In 2018, circulating strains clustered into multiple subgroups in the B3 and A2 subclades, with different phylogenetic origins. Clusters in subclade B3 emerged from strains circulating primarily in the US and Europe in 2016, though some had deeper roots linking to Asian strains, while clusters in A2 traced back to strains detected in East Asia in 2015-2016. In 2018, all sequences from the USA formed a distinct subgroup, containing only three non-US samples. Alongside the varied origins of seasonal strains, we found that diversification of these variants begins up to 18 months prior to the first diagnostic detection during a EV-D68 season. EV-D68 displays strong signs of continuous antigenic evolution and all 2018 A2 strains had novel patterns in the putative neutralizing epitopes in the BC- and DE-loops. The pattern in the BC-loop of the USA B3 subgroup had not been detected on that continent before. Patients with EV-D68 in subclade A2 were significantly older than patients with a B3 subclade virus. In contrast to other subclades, the age distribution of A2 is distinctly bimodal and was found primarily among children and in the elderly. We hypothesize that EV-D68’s rapid evolution of surface proteins, extensive diversity, and high rate of geographic mixing could be explained by substantial reinfection of adults. Better understanding of evolution and immunity across diverse viral pathogens, including EV-D68 and SARS-CoV-2, is critical to pandemic preparedness in the future.
dc.language.isoeng
dc.publisherPublic Library of Science
dc.relation.ispartofseriesPLoS Pathogens;18(5)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectDemografia
dc.subjectMalalties transmissibles - Transmissió
dc.subjectVirosis - Epidemiologia
dc.subject.meshEnterovirus D, Human
dc.subject.mesh/genetics
dc.subject.meshDisease Outbreaks
dc.subject.meshDemography
dc.titleEvolution, geographic spreading, and demographic distribution of Enterovirus D68
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1371/journal.ppat.1010515
dc.subject.decsenterovirus humano D
dc.subject.decs/genética
dc.subject.decsbrotes de enfermedades
dc.subject.decsdemografía
dc.relation.publishversionhttps://doi.org/10.1371/journal.ppat.1010515
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Hodcroft EB] Biozentrum, University of Basel, Basel, Switzerland. Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland. Swiss Institute of Bioinformatics, Basel, Switzerland. [Dyrdak R] Department of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden. Department of Microbiology, Tumor and Cell Biology, Karolinska Institute, Stockholm, Sweden. [Andrés C, Antón A] Unitat de Virus Respiratoris, Secció de Virologia, Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Egli A, Reist J] Clinical Bacteriology and Mycology, University Hospital Basel, Basel, Switzerland. Applied Microbiology Research, Department of Biomedicine, University of Basel, Basel, Switzerland. [García Martínez de Artola D] Department of Clinical Microbiology, Hospital Universitario Nuestra Señora de Candelaria, Tenerife, Spain
dc.identifier.pmid35639811
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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