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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorBorras Bermejo, Blanca
dc.contributor.authorPiñana Moro, Maria
dc.contributor.authorAndrés Verges, Cristina
dc.contributor.authorZules Oña, Ricardo Gabriel
dc.contributor.authorGonzález Sánchez, Alejandra
dc.contributor.authorEsperalba Esquerra, Juliana
dc.contributor.authorPares Badell, Oleguer
dc.contributor.authorGarcia Cehic, Damir
dc.contributor.authorRando Segura, Ariadna
dc.contributor.authorCampos Martinez, Carolina
dc.contributor.authorCodina Grau, Gema
dc.contributor.authorMartin Perez, Maria Carmen
dc.contributor.authorCastillo Oliveda, Carla
dc.contributor.authorGarcía-Comuñas, Karen
dc.contributor.authorVásquez-Mercado, Rodrigo
dc.contributor.authorMartins-Martins, Reginald
dc.contributor.authorColomer Castell, Sergi
dc.contributor.authorPumarola Suñé, Tomàs
dc.contributor.authorCampins Martí, Magda
dc.contributor.authorQuer Sivila, Josep
dc.contributor.authorAntón Pagarolas, Andres
dc.date.accessioned2022-09-12T08:37:45Z
dc.date.available2022-09-12T08:37:45Z
dc.date.issued2022-05
dc.identifier.citationBorras-Bermejo B, Piñana M, Andrés C, Zules R, González-Sánchez A, Esperalba J, et al. Characteristics of 24 SARS-CoV-2-Sequenced Reinfection Cases in a Tertiary Hospital in Spain. Front Microbiol. 2022 May;13:876409.
dc.identifier.issn1664-302X
dc.identifier.urihttp://hdl.handle.net/11351/8142
dc.descriptionSARS-CoV-2; Clinical features; Reinfection
dc.descriptionSARS-CoV-2; Características clínicas; Reinfección
dc.description.abstractBackground: Since the emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the main concern is whether reinfections are possible, and which are the associated risk factors. This study aims to describe the clinical and molecular characteristics of 24 sequence-confirmed reinfection SARS-CoV-2 cases over 1 year in Barcelona (Catalonia, Spain). Methods: Patients with > 45 days between two positive PCR tests regardless of symptoms and negative tests between episodes were initially considered as suspected reinfection cases from November 2020 to May 2021. Whole-genome sequencing (WGS) was performed to confirm genetic differences between consensus sequences and for phylogenetic studies based on PANGOLIN nomenclature. Reinfections were confirmed by the number of mutations, change in lineage, or epidemiological criteria. Results: From 39 reported suspected reinfection cases, complete viral genomes could be sequenced from both episodes of 24 patients, all were confirmed as true reinfections. With a median age of 44 years (interquartile range [IQR] 32–65), 66% were women and 58% were healthcare workers (HCWs). The median days between episodes were 122 (IQR 72–199), occurring one-third within 3 months. Reinfection episodes were frequently asymptomatic and less severe than primary infections. The absence of seroconversion was associated with symptomatic reinfections. Only one case was reinfected with a variant of concern (VOC). Conclusion: Severe acute respiratory syndrome coronavirus 2 reinfections can occur in a shorter time than previously reported and are mainly found in immunocompetent patients. Surveillance through WGS is useful to identify viral mutations associated with immune evasion.
dc.language.isoeng
dc.publisherFrontiers Media
dc.relation.ispartofseriesFrontiers in Microbiology;13
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectCOVID-19 (Malaltia) - Recaiguda
dc.subjectGenomes microbials
dc.subjectCOVID-19 (Malaltia) - Hospitals
dc.subject.meshCoronavirus Infections
dc.subject.meshGenome, Viral
dc.subject.meshTertiary Care Centers
dc.titleCharacteristics of 24 SARS-CoV-2-Sequenced Reinfection Cases in a Tertiary Hospital in Spain
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3389/fmicb.2022.876409
dc.subject.decsinfecciones por Coronavirus
dc.subject.decsgenoma viral
dc.subject.decscentros de asistencia terciaria
dc.relation.publishversionhttps://doi.org/10.3389/fmicb.2022.876409
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Borras-Bermejo B, Zules R, Parés-Badell O, Campins M] Servei de Medicina Preventiva i Epidemiologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Piñana M, Andrés C, González-Sánchez A, Esperalba J, Rando A, Codina MG, Pumarola T, Antón A] Unitat de Virus Respiratoris, Secció de Virologia, Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. CIBERINFEC, ISCIII-CIBER de Enfermedades Infecciosas, Instituto de Salud Carlos III, Madrid, Spain. [García-Cehic D, Quer J] Servei d’Hepatologia, Unitat Hepàtica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, Instituto de Salud Carlos III, Madrid, Spain. [Campos C, Colomer-Castell S] Servei d’Hepatologia, Unitat Hepàtica, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Martín MC, Castillo C, García-Comuñas K, Vásquez-Mercado R, Martins-Martins R] Unitat de Virus Respiratoris, Secció de Virologia, Servei de Microbiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
dc.identifier.pmid35722299
dc.identifier.wos000811822400001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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