Quan els excipients poden ser causa de problemes: recomanacions i consideracions davant un pacient amb necessitats especials
The excipients are inert substances and without therapeutic action, but they are necessary to manufacture of medicines. Although they are generally harmless, some may cause undesirable effects in patients with certain allergies or intolerances. For this reason, the current regulations establish which are the excipients of mandatory declaration and the information that must be included in the prospectus and the technical data sheet of the product. Lactose is an excipient widely used as a direct compression agent, agglutinating and diluting for capsules and tablets. In most patients with lactose intolerance it is unlikely that the lactose in the drugs have severe gastrointestinal symptoms, but in cases of intolerance it is recommended to use different formulations, change the route of administration, use alternative medicine without lactose or change of active principle. In addition to lactose intolerance, other examples of clinical situations related to the excipients are: gluten in patients with celiac disease; peanut oil and soybean oil and possible allergic reactions; the use of vaccines in patients with an allergy to egg protein; the adverse effects of some dyes and preservatives; carbohydrates in patients with a ketogenic diet; ethanol and the risk of alcohol intoxication, and the use of excipients of animal origin in patients with certain cultural or religious beliefs.
Excipients; Intolerance; Allergies
Diego L, Robert L. Quan els excipients poden ser causa de problemes: recomanacions i consideracions davant un pacient amb necessitats especials. Butll Inf Ter. 2017 Set;28(8):59-65.
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