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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorVogel-González, Marina
dc.contributor.authorTalló-Parra, Marc
dc.contributor.authorHerrera-Fernández, Víctor
dc.contributor.authorPérez-Vilaró, Gemma
dc.contributor.authorChillon Rodriguez, Miguel
dc.contributor.authorNogués, Xavier
dc.date.accessioned2021-07-19T09:59:40Z
dc.date.available2021-07-19T09:59:40Z
dc.date.issued2021-02-09
dc.identifier.citationVogel-González M, Talló-Parra M, Herrera-Fernández V, Pérez-Vilaró G, Chillón M, Nogués X, et al. Low zinc levels at admission associates with poor clinical outcomes in sars-cov-2 infection. Nutrients. 2021 Feb 9;13(2):562.
dc.identifier.issn2072-6643
dc.identifier.urihttp://hdl.handle.net/11351/6175
dc.descriptionCoronavirus SARS-CoV-2; COVID-19; 2019-nCoV; Clinical outcomes; Zinc
dc.description.abstractBackground: Zinc is an essential micronutrient that impacts host–pathogen interplay at infection. Zinc balances immune responses, and also has a proven direct antiviral action against some viruses. Importantly, zinc deficiency (ZD) is a common condition in elderly and individuals with chronic diseases, two groups with an increased risk for severe severe coronavirus disease 2019 (COVID-19) outcomes. We hypothesize that serum zinc content (SZC) influences COVID-19 disease progression, and thus might represent a useful biomarker. Methods: We ran an observational cohort study with 249 COVID-19 patients admitted in Hospital del Mar. We have studied COVID-19 severity and progression attending to SZC at admission. In parallel, we have studied severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) replication in the Vero E6 cell line modifying zinc concentrations. Findings: Our study demonstrates a correlation between serum zinc levels and COVID-19 outcome. Serum zinc levels lower than 50 µg/dL at admission correlated with worse clinical presentation, longer time to reach stability, and higher mortality. Our in vitro results indicate that low zinc levels favor viral expansion in SARS-CoV-2 infected cells. Interpretation: Low SZC is a risk factor that determines COVID-19 outcome. We encourage performing randomized clinical trials to study zinc supplementation as potential prophylaxis and treatment with people at risk of zinc deficiency.
dc.language.isoeng
dc.publisherMDPI
dc.relation.ispartofseriesNutrients;13(2)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectZinc - Efectes fisiològics
dc.subjectCOVID-19 (Malaltia)
dc.subject.meshCoronavirus Infections
dc.subject.meshZinc
dc.subject.mesh/pharmacology
dc.titleLow Zinc Levels at Admission Associates with Poor Clinical Outcomes in SARS-CoV-2 Infection
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.3390/nu13020562
dc.subject.decsinfecciones por Coronavirus
dc.subject.decszinc
dc.subject.decs/farmacología
dc.relation.publishversionhttps://www.mdpi.com/2072-6643/13/2/562
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Vogel-González M, Herrera-Fernández V] Laboratory of Molecular Physiology, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain. [Talló-Parra M, Pérez-Vilaró G] Molecular Virology Group, Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Barcelona, Spain. [Chillón M] Departament de Bioquímica i Biologia Molecular, Institut de Neurociències, Edifici H, Universitat Autònoma de Barcelona, Bellaterra, Spain. Unitat Mixta UAB-VHIR, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Institut Català de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. [Nogués X] Department of Internal Medicine, Hospital del Mar, Institut Mar d’Investigacions Mediques, Barcelona, Spain
dc.identifier.pmid33572045
dc.identifier.wos000622953700001
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2017-2020/PID2019-106755RB-I00
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2017-2020/PID2019-106959RB-I00
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2017-2020/CEX2018-000792-M
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PERIS2016-2020/2017SGR909
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/CB16%2F10%2F00245
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2017-2020/PI19%2F00019
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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