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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorToscano Guerra, Emily Marisol
dc.contributor.authorMartínez Gallo, Mónica
dc.contributor.authorArrese Muñoz, Iria
dc.contributor.authorGiné Vilalta, Anna
dc.contributor.authorDíaz Troyano, Noelia
dc.contributor.authorGabriel Medina, Pablo
dc.contributor.authorRiveiro Barciela, Maria del Mar
dc.contributor.authorLabrador Horrillo, Moisés
dc.contributor.authorMartínez Valle, Fernando
dc.contributor.authorSánchez Montalvá, Adrián
dc.contributor.authorHernández González, Manuel
dc.contributor.authorPujol Borrell, Ricardo
dc.contributor.authorRodríguez Frias, Francisco
dc.contributor.authorFerrer Costa, Roser
dc.contributor.authorPaciucci Barzanti, Rosanna
dc.date.accessioned2022-08-19T09:33:39Z
dc.date.available2022-08-19T09:33:39Z
dc.date.issued2022-03-29
dc.identifier.citationToscano-Guerra E, Martínez-Gallo M, Arrese-Muñoz I, Giné A, Díaz-Troyano N, Gabriel-Medina P, et al. Recovery of serum testosterone levels is an accurate predictor of survival from COVID-19 in male patients. BMC Med. 2022 Mar 29;20:129.
dc.identifier.issn1741-7015
dc.identifier.urihttp://hdl.handle.net/11351/8022
dc.descriptionCOVID-19; Immune phenotype; Survival
dc.description.abstractBackground SARS-CoV-2 infection portends a broad range of outcomes, from a majority of asymptomatic cases to a lethal disease. Robust correlates of severe COVID-19 include old age, male sex, poverty, and co-morbidities such as obesity, diabetes, and cardiovascular disease. A precise knowledge of the molecular and biological mechanisms that may explain the association of severe disease with male sex is still lacking. Here, we analyzed the relationship of serum testosterone levels and the immune cell skewing with disease severity in male COVID-19 patients. Methods Biochemical and hematological parameters of admission samples in 497 hospitalized male and female COVID-19 patients, analyzed for associations with outcome and sex. Longitudinal (in-hospital course) analyses of a subcohort of 114 male patients were analyzed for associations with outcome. Longitudinal analyses of immune populations by flow cytometry in 24 male patients were studied for associations with outcome. Results We have found quantitative differences in biochemical predictors of disease outcome in male vs. female patients. Longitudinal analyses in a subcohort of male COVID-19 patients identified serum testosterone trajectories as the strongest predictor of survival (AUC of ROC = 92.8%, p < 0.0001) in these patients among all biochemical parameters studied, including single-point admission serum testosterone values. In lethal cases, longitudinal determinations of serum luteinizing hormone (LH) and androstenedione levels did not follow physiological feedback patterns. Failure to reinstate physiological testosterone levels was associated with evidence of impaired T helper differentiation and augmented circulating classical monocytes. Conclusions Recovery or failure to reinstate testosterone levels is strongly associated with survival or death, respectively, from COVID-19 in male patients. Our data suggest an early inhibition of the central LH-androgen biosynthesis axis in a majority of patients, followed by full recovery in survivors or a peripheral failure in lethal cases. These observations are suggestive of a significant role of testosterone status in the immune responses to COVID-19 and warrant future experimental explorations of mechanistic relationships between testosterone status and SARS-CoV-2 infection outcomes, with potential prophylactic or therapeutic implications.
dc.language.isoeng
dc.publisherBMC
dc.relation.ispartofseriesBMC Medicine;20
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectCOVID-19 (Malaltia)
dc.subjectTestosterona
dc.subjectHomes
dc.subject.meshTestosterone
dc.subject.meshMale
dc.subject.meshCoronavirus Infections
dc.titleRecovery of serum testosterone levels is an accurate predictor of survival from COVID-19 in male patients
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1186/s12916-022-02345-w
dc.subject.decstestosterona
dc.subject.decsmasculino
dc.subject.decsinfecciones por Coronavirus
dc.relation.publishversionhttps://doi.org/10.1186/s12916-022-02345-w
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Toscano-Guerra E] Servei de Bioquímica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Laboratori de Senyalització Cel•lular i Progressió del Càncer, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Universidad Peruana Cayetano Heredia, Lima, Perú. [Martínez-Gallo M, Arrese-Muñoz I, Hernández-González M, Pujol Borrell R] Servei d’Immunologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Giné A, Paciucci R] Servei de Bioquímica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Laboratori de Senyalització Cel•lular i Progressió del Càncer, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Díaz-Troyano N, Gabriel-Medina P, Rodríguez-Frias F, Ferrer R] Servei de Bioquímica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. [Riveiro-Barciela M, Labrador-Horrillo M, Martinez-Valle F] Servei de Medicina Interna, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Montalvá AS] Servei de Malalties Infeccioses, Centre de Salut Internacional i Malalties Transmissibles Drassanes - Vall d'Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
dc.identifier.pmid35351135
dc.identifier.wos000774989100001
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/RTI2018-096055-B-I00
dc.relation.projectidinfo:eu-repo/grantAgreement/ES/PE2013-2016/PI18%2F00346
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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