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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorVakurov, Alexander
dc.contributor.authorDrummond-Brydson, Rik
dc.contributor.authorWilliam, Nicola
dc.contributor.authorSanver, Didem
dc.contributor.authorBastús, Neus G
dc.contributor.authorMoriones, Oscar Hernando
dc.contributor.authorFranco Puntes, Victor
dc.contributor.authorNelson, Andrew
dc.date.accessioned2022-09-07T11:32:15Z
dc.date.available2022-09-07T11:32:15Z
dc.date.issued2022-05-10
dc.identifier.citationVakurov A, Drummond-Brydson R, William N, Sanver D, Bastúsbastús N, Moriones OH, et al. Heterogeneous Rate Constant for Amorphous Silica Nanoparticle Adsorption on Phospholipid Monolayers. Langmuir. 2022 May 10;38(18):5372–5380.
dc.identifier.issn0743-7463
dc.identifier.urihttp://hdl.handle.net/11351/8046
dc.descriptionNanoparticle; Phospholipid Monolayers
dc.description.abstractThe interaction of amorphous silica nanoparticles with phospholipid monolayers and bilayers has received a great deal of interest in recent years and is of importance for assessing potential cellular toxicity of such species, whether natural or synthesized for the purpose of nanomedical drug delivery and other applications. This present communication studies the rate of silica nanoparticle adsorption on to phospholipid monolayers in order to extract a heterogeneous rate constant from the data. This rate constant relates to the initial rate of growth of an adsorbed layer of nanoparticles as SiO2 on a unit area of the monolayer surface from unit concentration in dispersion. Experiments were carried out using the system of dioleoyl phosphatidylcholine (DOPC) monolayers deposited on Pt/Hg electrodes in a flow cell. Additional studies were carried out on the interaction of soluble silica with these layers. Results show that the rate constant is effectively constant with respect to silica nanoparticle size. This is interpreted as indicating that the interaction of hydrated SiO2 molecular species with phospholipid polar groups is the molecular initiating event (MIE) defined as the initial interaction of the silica particle surface with the phospholipid layer surface promoting the adsorption of silica nanoparticles on DOPC. The conclusion is consistent with the observed significant interaction of soluble SiO2 with the DOPC layer and the established properties of the silica–water interface.
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.relation.ispartofseriesLangmuir;38(18)
dc.rightsAttribution 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.sourceScientia
dc.subjectNanopartícules
dc.subjectNanotecnologia
dc.subjectFosfolípids
dc.subject.meshNanoparticles
dc.subject.meshNanotechnology
dc.subject.meshPhospholipids
dc.titleHeterogeneous Rate Constant for Amorphous Silica Nanoparticle Adsorption on Phospholipid Monolayers
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.1021/acs.langmuir.1c03155
dc.subject.decsnanopartículas
dc.subject.decsnanotecnología
dc.subject.decsfosfolípidos
dc.relation.publishversionhttps://doi.org/10.1021/acs.langmuir.1c03155
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Vakurov A, Nelson AL] School of Chemistry, University of Leeds, Leeds LS2 9JT, U.K. [Drummond-Brydson R] School of Chemical and Process Engineering, University of Leeds, Leeds LS2 9JT, U.K. [William N] School of Chemistry, University of Leeds, Leeds LS2 9JT, U.K. Didem Sanver − Department of Food Engineering, Faculty of Engineering, Necmettin Erbakan University, Konya 42050, Turkey. [Sanver D] Department of Food Engineering, Faculty of Engineering, Necmettin Erbakan University, Konya 42050, Turkey. [Bastús N] Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, The Barcelona Institute of Science and Technology, Barcelona 08193, Spain. [Moriones OH] Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, The Barcelona Institute of Science and Technology, Barcelona 08193, Spain; Universitat Autònoma de Barcelona, Bellaterra, Spain. [Puntes V] Catalan Institute of Nanoscience and Nanotechnology (ICN2), CSIC, The Barcelona Institute of Science and Technology, Barcelona 08193, Spain. Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. ICREA, Barcelona 08010, Spain
dc.identifier.pmid35471829
dc.identifier.wos000813288200001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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