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dc.contributorVall d'Hebron Barcelona Hospital Campus
dc.contributor.authorSaegeman, Veroniek
dc.contributor.authorCohen, Marta C
dc.contributor.authorAbasolo, Lydia
dc.contributor.authorRello Condomines, Jordi
dc.contributor.authorFernández-Gutierrez, Benjamín
dc.contributor.authorFernandez-Rodriguez, Amparo
dc.date.accessioned2022-09-14T08:14:50Z
dc.date.available2022-09-14T08:14:50Z
dc.date.issued2022-06
dc.identifier.citationSaegeman V, Cohen MC, Abasolo L, Rello J, Fernandez-Gutierrez B, Fernandez-Rodriguez A. Positive airway pressure longer than 24 h is associated with histopathological volutrauma in severe COVID-19 pneumonia—an ESGFOR based narrative case-control review. Ann Transl Med. 2022 Jun;10(11):644.
dc.identifier.issn2305-5847
dc.identifier.urihttp://hdl.handle.net/11351/8190
dc.descriptionSARS-CoV-2; Post-mortem microbiology; Volutrauma
dc.description.abstractBackground and Objective: A thorough understanding of the pathogenic mechanisms elicited by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) still requires further research. Until recently, only a restricted number of autopsies have been performed, therefore limiting the accurate knowledge of the lung injury associated with SARS-CoV-2. A multidisciplinary European Society of Clinical Microbiology and Infectious Diseases (ESCMID) Study Group of Forensic and Post-mortem Microbiology-ESGFOR team conducted a non-systematic narrative literature review among coronavirus 2019 disease (COVID-19) pneumonia cases assessing the histopathological (HP) effects of positive airways pressure. HP lung features were recorded and compared between mechanically ventilated (>24 hours) and control (ventilation <24 hours) patients. A logistic regression analysis was performed to identify associations between mechanical ventilation (MV) and HP findings. Methods: A PubMed and MEDLINE search was conducted in order to identify studies published between March 1st 2020 and June 30th 2021. Key Content and Findings: Seventy patients (median age: 69 years) from 24 studies were analysed, among whom 38 (54.2%) underwent MV longer than 24 hours. Overall, main HP features were: diffuse alveolar damage (DAD) in 53 (75.7%), fibrosis (interstitial/intra-alveolar) in 43 (61.4%), vascular damage—including thrombosis/emboli- in 41 (58.5%), and endotheliitis in only 8 (11.4%) patients. Association of DAD, fibrosis and vascular damage was detected in 30 (42.8%) patients. Multivariate analysis, adjusted by age and gender, identified MV >24 hours as an independent variable associated with DAD (OR =5.40, 95% CI: 1.48–19.62), fibrosis (OR =3.88, 95% CI: 1.25–12.08), vascular damage (OR =5.49, 95% CI: 1.78–16.95) and association of DAD plus fibrosis plus vascular damage (OR =6.99, 95% CI: 2.04–23.97). Conclusions: We identified that patients mechanically ventilated >24 hours had a significantly higher rate of pulmonary injury on histopathology independently of age and gender. Our findings emphasize the importance of maintaining a protective ventilator strategy when subjects with COVID-19 pneumonia undergo intubation.
dc.language.isoeng
dc.publisherAME Publishing Company
dc.relation.ispartofseriesAnnals of Translational Medicine;10(11)
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceScientia
dc.subjectCOVID-19 (Malaltia) - Complicacions
dc.subjectRespiració artificial - Complicacions
dc.subjectPneumònia vírica
dc.subject.meshCoronavirus Infections
dc.subject.meshRespiration, Artificial
dc.subject.mesh/adverse effects
dc.subject.meshPneumonia
dc.titlePositive airway pressure longer than 24 h is associated with histopathological volutrauma in severe COVID-19 pneumonia—an ESGFOR based narrative case-control review
dc.typeinfo:eu-repo/semantics/article
dc.identifier.doi10.21037/atm-22-605
dc.subject.decsinfecciones por Coronavirus
dc.subject.decsrespiración artificial
dc.subject.decs/efectos adversos
dc.subject.decsneumonía
dc.relation.publishversionhttp://dx.doi.org/10.21037/atm-22-605
dc.type.versioninfo:eu-repo/semantics/publishedVersion
dc.audienceProfessionals
dc.contributor.organismesInstitut Català de la Salut
dc.contributor.authoraffiliation[Saegeman V] Department of Microbiology and Infection Control, Vitaz, Sint-Niklaas, Belgium. Department of Infection Control, University Hospitals, Leuven, Belgium. [Cohen MC] Histopathology Department, Sheffield Children’s NHS FT, Sheffield, UK. [Abasolo L] Rheumatology Department, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IDISSC), Hospital Clínico San Carlos, Madrid, Spain. [Rello J] Grup de Recerca Clínica/Innovació en la Pneumònia i Sèpsia (CRIPS), Vall d'Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica En Red de Enfermedades Respiratorias (CIBERES), Madrid, Spain. Clinical Research, CHRU Nimes, Nimes, France. [Fernandez-Gutierrez B] Rheumatology Department, Hospital Clinico San Carlos, Madrid, Spain. [Fernandez-Rodriguez A] Microbiology Laboratory, Biology Department, Instituto Nacional de Toxicología y Ciencias Forenses, Las Rozas de Madrid, Madrid, Spain
dc.identifier.pmid35813341
dc.identifier.wos000809575700001
dc.rights.accessrightsinfo:eu-repo/semantics/openAccess


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